Eats Shell Fish
type: Class
type: QualityValue
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: FOODON_03411433
notation: 230
definition: The attribute of eating shell fish.
subclass of: Dietary Intake

Non-Spontaneous Preterm Birth
type: QualityValue
notation: 60
type: Class
subclass of: Preterm Birth

Housing Characteristic
definition: Housing Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: StudyIndicator

Post-Pregnancy
subclass of: From Birth
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000417
type: Class
definition: The period after birth.
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing

Electron-Detachment Dissociation (EDD)
subclass of: TandemMassSpectrometry
type: Class

plaque forming unit
notation: pfu
type: SIO_000074

mono-2-ethyl-5-hydroxyhexyl terephthalate (DEHTP)
notation: MEHHTP

Minuend
definition: In a difference expression, the minuend is the quantity or number from which another is to be subtracted.
type: QuantityVariable
type: Class
subclass of: SIO_000052

Arsenobetaine
subclass of: Arsenic Species
notation: Arsenobetaine
type: Class

2-Thioxothiazolidine-4-carboxylic acid
subclass of: Volatile Organic Compound
type: Class
editorial note: To Do: align with CHEBI.
notation: TTCA

Cerebral Malaria
type: Class
notation: 126
type: QualityValue
subclass of: Malaria
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

Gestational Age
subclass of: Birth Outcome
type: Class
subclass of: Age
definition: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization
was approved by: PER-Jeanette-Stingone
type: QuantityVariable

Full Time Employment
type: Class
subclass of: Occupation
type: QualityValue
notation: 64
definition: Employed for a standard number of hours of working time, at least 50% or 20 hours per week.

Increased Body Weight
notation: 72
type: QualityValue
subclass of: Body Weight Quality
type: Class
definition: BMI > 25
subclass of: Restriction
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
  on property: isAttributeOf

Used to take asthma control medications but no longer
type: QualityValue
type: Class
subclass of: Asthma Controller Use
subclass of: Has taken asthma control medications
subclass of: Restriction
  some values from: Used to take but no longer
  on property: SIO_000217
notation: 276

Austism Spectrum Disorder related condition
type: Class
type: QualityValue
definition: Quality refers to children who do not meet DSM criteria for ASD but have scores on ADOS and Mullens that suggest related outcome. All potential options seems to fall under this class from the Autism Ontology
notation: 150
subclass of: Developmental Disorder of Mental Health

Socioeconomic Status Index
editorial note: This is a specific index, derived from other variables. So, it should somehow be connected to this variables. Also, we may want to be more specific about the type of index that it is. Perhaps there should be a general SESIndex and then subclasses of specific measures?
subclass of: SIO_000052
type: Class
subclass of: Socioeconomic Status
type: QuantityVariable
definition: A measure of SES.

adrenic acid
subclass of: Fatty Acid
type: Class
notation: C224N6

Abnormality of the respiratory system
type: Class
subclass of: Health Outcome
type: QualityVariable

Household Appliance Count
type: QuantityVariable
was approved by: PER-Jeanette-Stingone
subclass of: Housing Characteristic
type: Class
definition: Total number of appliances that can be found in the home.
subclass of: SIO_000794

Platinum
type: Class
notation: Pt
subclass of: Metal
definition: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) PLATINUM is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".

Seizures
type: QualityValue
definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.
type: Class
subclass of: Phenotype
notation: 125

White Non-Hispanic
subclass of: ExO_0000158
subclass of: Non-Hispanic Ethnicity
type: Class
notation: 214
type: QualityValue

Garage
type: Class
notation: 235
definition: A building, or part of a building primarily used for housing a motor vehicle or vehicles.
subclass of: Human Dwelling
type: QualityValue

phthalic acid
subclass of: Phthalate
notation: PA
definition: PHYSICAL DESCRIPTION: White crystals or fine white powder. (NTP, 1992)
type: Class

Anthropometry
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: StudyIndicator
definition: Attributes pertaining to the scientific study of the measurements and proportions of the human body.

Private Insurance
subclass of: Private Insurance or Self Pay
type: QualityValue
notation: 103
type: Class

Income 50001 to 75000
type: QualityValue
notation: 163
type: Class
definition: Personal or family annual income bwtween $50,001 and $75,000
subclass of: Household Income

N-Acetyl-S-(n-propyl)-L-cysteine(ng/mL)
notation: VOCBPM
subclass of: Volatile Organic Compound
type: Class
editorial note: To Do: align with CHEBI.

weber
type: SIO_000074
notation: Wb

Cotinine
type: Class
definition: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
notation: COT
subclass of: Tobacco Metabolite

Behavior Rating Inventory of Executive Function – Preschool Version
subclass of: Neurocognitive Assessment
type: Class
definition: Standardized rating scale designed to specifically measure the range of executive function in preschool-aged children

Mobile Home
notation: 247
type: Class
type: QualityValue
subclass of: Human Dwelling

E-Cigarette Puffs Per Day
subclass of: SIO_000794
type: QuantityVariable
subclass of: E-Cigarette Use
type: Class

Methyl Paraben
subclass of: Paraben
type: Class
definition: Methylparaben is a Standardized Chemical Allergen. The physiologic effect of methylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of methylparaben is Allergens.
notation: MePB

dyne per cm
notation: dyn/cm
type: SIO_000074

Quality Control
subclass of: Analyte
type: Class
definition: The value contains quality control data

Propyl paraben
subclass of: Paraben
definition: Propylparaben is a Standardized Chemical Allergen. The physiologic effect of propylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of propylparaben is Allergens.
type: Class
notation: PrPB

Departure
type: QualityValue
type: Class
definition: The act of leaving a destination.
notation: 174
subclass of: Destination

N-Acel-S-(2, 2-Dichlorvinyl)-L-cys(ng/mL)
subclass of: Volatile Organic Compound
notation: VOC2DC
editorial note: To Do: align with CHEBI.
type: Class

Non-Biological Relative
subclass of: Relative
definition: People that are considered relatives but are not related by blood. This includes relatives by marriage, adoption, or fosterage.
type: Class

Elementary School
type: Class
type: QualityValue
definition: Finished Elementary School
subclass of: Some Elementary School
notation: 15
was approved by: PER-Jim-McCusker

Perfluorooctanesulfonamide
subclass of: PFC
notation: PFOSA
type: Class

Lipemic and turbid
type: Class
subclass of: SIO_001167

African American
was approved by: PER-Jeanette-Stingone
notation: 8
subclass of: Non-White
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American".
type: QualityValue
type: Class
subclass of: Race

Prenatal Nonsmoker
type: Class
type: QualityValue
editorial note: Should this be a subClassOf PregnancyCharactistic as well?
definition: Could be a former smoker or a non-smoker, so neither should be encoded as the superclass.
subclass of: Non-smoker
notation: 76

times per week
notation: times/week
type: SIO_000074
type: SIO_000794

Bismuth
subclass of: Metal
notation: Bi
definition: BISMUTH is a metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
type: Class

Interleukin-25
subclass of: Protein
notation: IL17EIL25
type: Class

Competitive Immunoassay
type: Class
subclass of: Immunoassay

Apgar Score
type: QuantityVariable
subclass of: SIO_001112
type: Class
definition: A method to quickly summarize the health of newborn children. The Apgar score was invented by Virginia Apgar in 1952 when Apgar was an anesthesiologist who developed the score in order to ascertain the effects of obstetric anesthesia on babies. The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).
subclass of: Birth Outcome
was approved by: PER-Jeanette-Stingone
subclass of: Restriction
  on property: hasValue
  all values from: Datatype
    intersection of: Datatype
      on datatype: integer
      with restrictions:
        min inclusive: 0
    intersection of: Datatype
      with restrictions:
        max inclusive: 10
      on datatype: integer

Value less than LOD
subclass of: SIO_001167
type: Class

Single-Family House
definition: A residential building designed to hold one family.
notation: 175
type: QualityValue
subclass of: Residential Building
type: Class

4-Hydroxybenzoic acid
subclass of: Environmental Phenol
type: Class
notation: HB4

millimolar
type: SIO_000074
notation: mM

Unknown Race
subclass of: Race
type: QualityValue
definition: Unknown Race
notation: 48
type: Class

femtoliter
notation: fl
type: SIO_000074

Smoker
notation: 105
type: QualityValue
type: Class
subclass of: Smoking Status
definition: The quality of smoking cigarettes.

microgram per milliliter
type: SIO_000074
notation: µg/ml

N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine
notation: MHBMA1
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.

11 or More Residence Building
definition: A residential building that contains eleven or more apartments, town houses, condos, or other single family dwelling spaces.
notation: 234
type: QualityValue
subclass of: Multi Residence Building
type: Class

Homemaker
notation: 68
definition: A person who manages a home as their main daily activity.
type: QualityValue
subclass of: Occupation
type: Class

parts per million
notation: ppm
type: SIO_000074

Interleukin-2
notation: IL2
type: Class
subclass of: Protein

Education
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000026
subclass of: Demographic
type: QualityVariable
subclass of: Socioeconomic Status
type: Class
definition: The act or process of imparting or acquiring knowledge.

pixels per inch
type: SIO_000074
notation: p/in

Plutonium
notation: Pu
type: Class
subclass of: Metal
definition: Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.

Technical Post Junior College
type: QualityValue
subclass of: Technical School
notation: 93
type: Class
definition: Attended a Technical Post Junior College
subclass of: Education
was approved by: PER-Jeanette-Stingone

Liquid Chromatography Instrument
was approved by: PER-Jim-McCusker
subclass of: Chromatography Instrument
type: Class
definition: A separation technique in which the mobile phase is a liquid. It can be carried out either in a column or a plane. Present day liquid chromatography that generally utilizes very small packing particles and a relatively high pressure is referred to as high performance liquid chromatography (HPLC).

Copper
type: Class
subclass of: Metal
notation: Cu
definition: COPPER is a heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Non-ecigarette user
type: QualityValue
subclass of: Smoking Status
type: Class
definition: Doesn't use e-cigarettes.
notation: 199

enzyme-linked immunosorbent assay (ELISA)
subclass of: Immunoassay
definition: ELISA is an immunoassay that uses antibodies and color change to identify a substance (Wikipedia)
type: Class

2, 3', 4, 4'-Tetrabromodiphenyl ether
editorial note: To Do: align with CHEBI.
subclass of: Polybrominated Diphenyl Ether
notation: BDE66
type: Class

Genotype
subclass of: Medical History
type: Class

Arsenic (V) Acid
subclass of: Arsenic Species
notation: Arsenic (V) Acid
type: Class

Physical Activity and Fitness
definition: Physical Activity and Fitness Indicator Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone
type: Class

Pregnancy Complication
type: Class
type: QualityValue
notation: 75
subclass of: Pregnancy Characteristic

Daily Exposure to Second Hand Smoke from E-cigarettes
subclass of: environmental e-cigarette smoke exposure
type: QualityValue
notation: 255
type: Class

8-isoprostane
subclass of: Biomolecule
type: Class
subclass of: Biological Response

femtomolar
type: SIO_000074
notation: fM

High-Performance Liquid Chromatography-Mass Spectrometry
type: Class
subclass of: Mass Spectrometer
definition: Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin. Therefore, LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries.
subclass of: Liquid Chromatography–Mass Spectrometer
subclass of: High-Performance Liquid Chromatography
was approved by: PER-Jim-McCusker

Carbon Tetrachloride
notation: CTET
type: Class
subclass of: Volatile Organic Compound
definition: CARBON TETRACHLORIDE is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

Underweight
subclass of: Underweight/Normal
subclass of: Restriction
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
  on property: isAttributeOf
subclass of: Body Weight Quality
type: QualityValue
type: Class
notation: 99
definition: BMI < 18.5

Atomic Absorption Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

million parts per microgram
notation: x106 µL
type: SIO_000074

2, 2', 4, 4', 5, 5'-Hexabromobiphenyl
notation: PBB153
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Polybrominated Diphenyl Ether

Separated
notation: 41
subclass of: Married
definition: Indicates a person living apart from his/her spouse by legal arrangement.
type: Class
type: QualityValue

Owns Home
type: QualityValue
type: Class
notation: 147
definition: This person owns the home they live in.
subclass of: Home Ownership

Fms-related tyrosine kinase 3 ligand
subclass of: Protein
notation: FLT3L
type: Class

mass percentage
type: SIO_000074
notation: w/w

square millimeter
type: SIO_000074
notation: mm2

Born Fifth
notation: 240
type: QualityValue
subclass of: Birth Order
subclass of: NCIT C54567
definition: The fifth born child
type: Class

mono-isodecyl phthalate
type: Class
notation: mIDP
subclass of: Phthalate

mono (5-carboxy-2-ethylpentyl) phthalate (DEHP)
notation: MCEPP
subclass of: Phthalate
type: Class

unit per liter
type: SIO_000074
notation: U/l

Relative
definition: Broadly, kinship patterns may be considered to include people related by both descent – i.e. social relations during development – and by marriage. Human kinship relations through marriage are commonly called "affinity" in contrast to the relationships that arise in one's group of origin, which may be called one's descent group. In some cultures, kinship relationships may be considered to extend out to people an individual has economic or political relationships with, or other forms of social connections. Within a culture, some descent groups may be considered to lead back to gods or animal ancestors (totems). This may be conceived of on a more or less literal basis.
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Relative
    intersection of: SIO_000485
  on property: inRelationTo
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000016
type: Class
subclass of: Demographic

Granulocyte-macrophage colony-stimulating factor
notation: GMCSF
subclass of: Protein
type: Class

Weight for Height Z-Score
subclass of: Z-Score
type: Class
subclass of: SIO_001245
type: QuantityVariable
definition: Z-Score of the weight/height ratio at a given age.

radian per second per second
notation: alpha
type: SIO_000074

Eats Fried Fish
notation: 229
subclass of: Dietary Intake
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: FOODON_03310717
definition: The attribute of eating fried fish.
type: Class
type: QualityValue

Caregiver
definition: a paid or unpaid and without formal training member of a person's social network who helps them with activities of daily living. Caregiving is most commonly used to address impairments related to old age, disability, a disease, or a mental disorder.
subclass of: Demographic
type: Class
subclass of: SIO_000016

Short sample; sample probe picked up incomplete volume first time
type: Class
subclass of: SIO_001167

Has taken asthma control medications
subclass of: Asthma Controller Use
type: QualityValue
type: Class
disjoint with: Never takes asthma control medications
notation: 282

Previous Smoker
notation: 78
definition: The quality of having smoked in the past.
type: Class
subclass of: Smoking Status
type: QualityValue

Childhood
notation: 11
type: QualityValue
subclass of: Demographic
was approved by: PER-Jeanette-Stingone
subclass of: Developmental Quality
type: Class
definition: A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.

normal
notation: Norm
type: SIO_000074

N-Ace-S-(dimethylphenyl)-L-Cys(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCDPM
type: Class
subclass of: Volatile Organic Compound

microliter per kilogram
notation: µl/kg
type: SIO_000074

milliliter per kilogram
type: SIO_000074
notation: ml/kg

Interleukin-22
type: Class
notation: IL22
subclass of: Protein

eosinophilic esophagitis in remission
type: Class
subclass of: eosinophilic esophagitis
equivalent class: Restriction
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
  on property: isPhenotypeOf
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of less than 15 eosinophils per high-power field area, or 0.158 mm^2 (400x).

Underweight/Normal
subclass of: Body Weight Quality
type: Class
type: QualityValue
notation: 100
subclass of: Restriction
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
  on property: isAttributeOf

N-Acetyl-S-(2-hydroxypropyl)-L-cysteine
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: HPMA2

Quit Smoking
notation: 82
type: QualityValue
definition: Quit Smoking Cigarettes
type: Class
subclass of: Previous Smoker

Fluticasone furoate DPI (Arnuity Ellipta)
type: Class
subclass of: Asthma Controller Medication

Active Smoker
subclass of: Smoking Status
type: Class
definition: The quality of actively smoking.
notation: 2
type: QualityValue
editorial note: How is this different from "smoker'?

picovolt
type: SIO_000074
notation: pV

N-Ace-S-(3-Hydroxypropyl)-L-Cys(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCHPM
type: Class
subclass of: Volatile Organic Compound

Mono-2-(carboxymethyl) hexyl phthalate
type: Class
notation: MCMHP
subclass of: Phthalate

Interleukin-17F
type: Class
notation: IL17F
subclass of: Protein

Interleukin-15
type: Class
subclass of: Protein
notation: IL15

Toluene
type: Class
subclass of: Volatile Organic Compound
notation: TOL
definition: Toluene is a widely used industrial solvent.

Household Income
subclass of: Socioeconomic Status
type: Class
subclass of: SIO_000052
was approved by: PER-Jeanette-Stingone
type: QuantityVariable
definition: A demographic parameter indicating the amount of earnings made by a family.

American Indian Or Alaskan Native
subclass of: Race
was approved by: PER-Jeanette-Stingone
subclass of: Non-White
notation: 5
definition: A person having origins in any of the original peoples of North and South America (including Central America) and who maintains tribal affiliation or community attachment.
type: QualityValue
type: Class

Pregnancy Cohort Study
type: Class
subclass of: CohortStudy

milligray
type: SIO_000074
notation: mGy

Sibling
type: Class
definition: One of two or more individuals having one or both parents in common. A male sibling is a brother, and a female sibling is a sister. In most societies throughout the world, siblings often grow up together, thereby facilitating the development of strong emotional bonds. The emotional bond between siblings is often complicated and is influenced by factors such as parental treatment, birth order, personality, and personal experiences outside the family. However, there are cases where siblings grow up in separate homes, in different environments.
subclass of: Relative
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      all values from: Sibling
      on property: hasRole
    intersection of: SIO_000485
  on property: inRelationTo
was approved by: PER-Jeanette-Stingone

watt
type: SIO_000074
notation: watt

mono-2-heptyl phthalate
type: Class
subclass of: Phthalate
notation: mHpP

gram
notation: g
type: SIO_000074

Fresh Vegetable Consumption Frequency
type: Class
definition: Frequency of Fresh Vegetable Consumption.
was approved by: PER-Jeanette-Stingone
subclass of: Diet Quantity
type: QuantityVariable

hour
notation: h
type: SIO_000074

N-Acetyl-S-(2, 2-dichlorovinyl)-L-cysteine
editorial note: To Do: align with CHEBI.
notation: DCVMA22
type: Class
subclass of: Volatile Organic Compound

Very turbid
type: Class
subclass of: SIO_001167

Dead
notation: 173
type: Class
subclass of: Destination
definition: The cessation of life.
type: QualityValue

T-Score
subclass of: Physical And Mental Assessment
definition: A method for converting an individual score into a standard form. While similar to a z-score, t-score is used when the conversion is made without knowledge of the population standard deviation and mean.
type: Class
subclass of: STATO_0000569

Mirex
notation: MIREX
type: Class
subclass of: Organochlorine Compound

Manganese
definition: MANGANESE is a trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
notation: Mn
subclass of: Metal
type: Class

did not precipitate
type: Class
subclass of: SIO_001167

Peripheral Blood Mononuclear Cell
type: Class
definition: Any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.
subclass of: Cell

Phenylglyoxylic acid(ng/mL)
notation: VOCPHG
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class

Gas Chromatography Instrument
type: Class
subclass of: Chromatography Instrument
was approved by: PER-Jim-McCusker
definition: Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.

millimeter
type: SIO_000074
notation: mm

counts per minute
notation: cpm
type: SIO_000074

Season
type: QualityValue
subclass of: Environmental Exposure
type: Class
notation: 209
subclass of: SIO_000417

formazin nephelometric unit
type: SIO_000074
notation: FNU

Lead
type: Class
notation: Pb
subclass of: Metal
definition: LEAD is a soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)

Hexachlorobenzene
subclass of: Organochlorine Compound
notation: HCB
type: Class

Shotgun Lipidomics
type: Class
subclass of: Electrospray Ionization Mass Spectrometry

Mandelic acid(ng/mL)
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class
notation: VOCMAD

mole
type: SIO_000074
notation: mol

Benzo[a]pyrene tetraol
subclass of: PAH
notation: BAPT
type: Class

N-Acetyl-S-(benzyl)-L-cysteine
editorial note: To Do: align with CHEBI.
notation: BMA
subclass of: Volatile Organic Compound
type: Class

Eats Rice
subclass of: Dietary Intake
type: QualityValue
definition: The attribute of eating rice.
type: Class
subclass of: Restriction
  some values from: FOODON_03301641
  on property: SIO SIO 000369
notation: 224

English Language
type: QualityValue
notation: 243
type: Class
definition: The English Language
subclass of: Acculturation

No Anti Malarial Use
notation: 140
type: Class
type: QualityValue
subclass of: Prescription Medication and Dietary Supplements

FVC Best Value
type: Class
subclass of: CMO_0000251
type: QualityVariable
definition: The best FVC value achieved by a subject during a series of FVC measurements.

White
was approved by: PER-Jeanette-Stingone
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
subclass of: Race
type: Class
type: QualityValue
notation: 102

Lab confirmed result
subclass of: SIO_001167
type: Class

Master's Degree
type: Class
notation: 143
subclass of: Higher Education
definition: The Master's Degree is an award that requires the successful completion of a program of study of at least the full-time equivalent of 1 but not more than two academic years of work beyond the bachelor's degree.
type: QualityValue
subclass of: Some Postgraduate

Forceps-Assisted Birth
definition: A vaginal birth with the assistance of forceps to extract the baby.
subclass of: Vaginal Birth
type: QualityValue
type: Class
notation: 25

Income 55,000 to 64,999
type: QualityValue
subclass of: Household Income
notation: 264
subclass of: Income 40001 to 70000
type: Class
subclass of: Income 50000 to 99999

Interferon lambda-2
subclass of: Protein
type: Class
notation: IL28A

2-hydroxychrysene
subclass of: PAH
type: Class
notation: CHRY2

Torn bag (Mitest intact, capped)
subclass of: SIO_001167
type: Class

Total nicotine
subclass of: Tobacco Metabolite
editorial note: Duplicate of NIC?
type: Class
notation: TNIC

Chromium
subclass of: Metal
definition: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002, 1985), chromium and some of its compounds have been listed as known carcinogens.
type: Class
notation: Cr

Markedly hemolyzed
subclass of: SIO_001167
type: Class

In Vitro Fertilization
notation: 50
subclass of: Assisted Reproductive Therapy
type: QualityValue
type: Class

Specimen analyzed with less than normal quantity
subclass of: SIO_001167
type: Class

Greater than 99th percentile
type: Class
subclass of: SIO_001167

Interleukin-10
type: Class
definition: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
notation: IL10
subclass of: Protein

Hemolyzed (covers all three levels) and debris present
subclass of: SIO_001167
type: Class

Repeat Caesarian Section
subclass of: Caesarian Section
notation: 21
type: Class
type: QualityValue
definition: Had Repeat Caesarian Section

tetracosanoic acid
definition: A C24 straight-chain saturated fatty acid.
type: Class
subclass of: Fatty Acid
notation: C240

2, 5-Dichlorophenol
type: Class
notation: DCP25
subclass of: Environmental Phenol
definition: PHYSICAL DESCRIPTION: Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 µg/L at 68-72°F; 33 µg/L at 86°F. Taste threshold 0.5 µg/L. (NTP, 1992)

United States of America
type: QualityValue
notation: 184

type 1 diabetes mellitus
notation: 180
type: Class
subclass of: DOID 9351
type: QualityValue

Urine
type: Class
definition: Excretion that is the output of a kidney [database_cross_reference: http://en.wikipedia.org/wiki/Urine][database_cross_reference: https://github.com/geneontology/go-ontology/issues/11025]
subclass of: Bodily Fluid

Summer
subclass of: Season
type: Class
notation: 212
type: QualityValue

Study Site
type: QualityVariable
definition: A facility in which study/protocol activities are conducted. [def-source: NCI]

N-A-S-(1-HydrxMet)-2-Prpn)-L-Cys(ng/mL)
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB1

Asian
notation: 6
subclass of: Non-White
subclass of: Race
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
type: Class
was approved by: PER-Jeanette-Stingone

Marital Status
was approved by: PER-Jeanette-Stingone
type: QualityVariable
type: Class
definition: A person's current conjugal status.
subclass of: NCIT C44456

Childhood Period
subclass of: Restriction
  all values from: Class
    intersection of: birthing
  on property: inRelationTo
subclass of: From Birth
definition: The age span ranging from birth to adolescence
type: Class
subclass of: SIO_000417

Cis-Nonachlor
notation: CNON
type: Class
subclass of: Organochlorine Compound

byte
notation: Byte
type: SIO_000074

Some College
notation: 85
type: QualityValue
subclass of: Higher Education
was approved by: PER-Jeanette-Stingone
definition: Indicates that a person has attended college but that they did not receive any degree.
type: Class

Operating Room
type: QualityValue
subclass of: Destination
notation: 171
definition: A room in a health care facility equipped for the performance of surgical operations and procedures.
type: Class

Community Recruit
notation: 272
type: QualityValue
subclass of: Population Group
type: Class

Income 10001 to 20000
type: QualityValue
subclass of: Household Income
type: Class
notation: 205

Unknown Education Level
type: Class
definition: Level of Education is not known
subclass of: Education
notation: 101
was approved by: PER-Jeanette-Stingone
type: QualityValue

Some College or Technical School
subclass of: Education
type: QualityValue
notation: 203
type: Class
subclass of: Higher Education

4-hydroxybenzophenone
subclass of: Benzophenone
type: Class
notation: OH4BP

Inpatient Encounter
subclass of: Destination
type: QualityValue
notation: 169
type: Class
definition: A patient encounter where a patient is admitted to a hospital or equivalent facility.

Neighbor
subclass of: Demographic
type: Class
subclass of: SIO_000016
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: SIO_000485
definition: A person living near or next door to another person.

birthing
type: Class
subclass of: Birth Outcome

Never exposed to second hand smoke
type: QualityValue
type: Class
subclass of: environmental tobacco smoke exposure
notation: 254

Boron
definition: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.
type: Class
notation: B
subclass of: Metal

Ultra High Performance Liquid Chromatography Instrument
definition: Modern HPLC systems have been improved to work at much higher pressures, and therefore are able to use much smaller particle sizes in the columns (<2 μm). These "Ultra High Performance Liquid Chromatography" systems or UHPLCs can work at up to 120 MPa (17, 405 lbf/in^2), or about 1200 atmospheres.
was approved by: PER-Jim-McCusker
type: Class
subclass of: High-Performance Liquid Chromatography

Quit Smoking Before Pregnancy
subclass of: Pregnancy Characteristic
notation: 81
type: Class
subclass of: Quit Smoking
type: QualityValue
subclass of: Prenatal Nonsmoker
definition: A Previous Smoker who Quit Smoking Before Pregnancy

Non-Hispanic Ethnicity
type: Class
type: QualityValue
definition: Non-Hispanic Ethnicity
notation: 58
was approved by: PER-Jeanette-Stingone
subclass of: Ethnicity

Spirometry Outcomes Met Guidelines
notation: 280
type: Class
subclass of: Restriction
  on property: SIO_000217
  some values from: SIO_001312
type: QualityValue
subclass of: Spirometry Outcome

nutrition intake
subclass of: Diet and Nutrition
type: Class
type: QualityVariable
definition: Nutrition intake is the process of taking in of nutrients, especially by eating or drinking, considered in relation to the body’s dietary needs.

Long Range Polymerase Chain Reaction
type: Class
subclass of: Polymerase Chain Reaction
definition: Amplification of DNA lengths that cannot typically be amplified using routine PCR methods or reagents. For simple DNA templates, polymerases optimized for Long Range PCR can amplify up to 30 kb and beyond. For complex, genomic templates, 20 kb is a typical target.
was approved by: PER-Jim-McCusker

micromolal
notation: µmol/kg
type: SIO_000074

2, 4, 5, 6-Tetrachlorophenol
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)
notation: TeCP2456
type: Class
subclass of: Environmental Phenol

Asthma Induced Reduced Play Or Activity
subclass of: GO_0048266
type: Class
type: QuantityVariable
subclass of: Restriction
  on property: SIO_001157
  some values from: wheezing or tightness in the chest or cough
subclass of: Physical And Mental Assessment
subclass of: HP_0000721

2, 4, 5-Trichlorophenol
type: Class
notation: TCP245
definition: Exposure to 2, 4, 5-trichlorophenol may occur during its production or use as a pesticide. Acute (short-term) dermal exposure to 2, 4, 5-trichlorophenol may burn skin in humans. It also irritates the eyes, nose, pharynx, and lungs in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of 2, 4, 5-trichlorophenol in humans. In one study, slight degenerative changes were observed in the liver and kidneys of rats chronically exposed to 2, 4, 5-trichlorophenol in their diet. EPA has classified 2, 4, 5-trichlorophenol as a Group D, not classifiable as to human carcinogenicity. PHYSICAL DESCRIPTION: Colorless needles, gray flakes or off-white lumpy solid. Phenolic odor. Formerly used as a fungicide and bactericide.
subclass of: Environmental Phenol

Home Ownership
type: QuantityVariable
definition: Who owns the home they live in.
subclass of: Demographic
type: Class

microcurie
type: SIO_000074
notation: µCi

3, 4-Dihydroxy-benzoic acid methyl ester
notation: OHMeP
subclass of: Environmental Phenol
type: Class

Spirometry Outcome
subclass of: NCIT C123984
subclass of: Physical And Mental Assessment
type: Class
type: QualityVariable
subclass of: Restriction
  on property: SIO_001157
  some values from: NCIT C85397

Electron Capture Dissociation (ECD)
type: Class
subclass of: TandemMassSpectrometry

1, 2-Dichloroethane
definition: Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
type: Class
subclass of: Volatile Organic Compound
notation: DE12

No FOL result; FOL = 8 ng/mL assumed
type: Class
subclass of: SIO_001167

microgray
type: SIO_000074
notation: µGy

monoisononyl phthalate
subclass of: Phthalate
notation: MIP
type: Class
editorial note: Duplicate of mINP?

Proton Pump Inhibitor Treatment
editorial note: UPDATE: Yes, add the prescription medication, either as an indicator or as a class under Medical Therapy. Whichever works for the ontology. Why isn't this listed under prescription medication? How do you differentiate between medical therapy and prescription medication?
type: Class
notation: 27
subclass of: Medical Therapy Procedure
type: QualityValue
definition: Proton Pump Inhibitor Treatment as a form of medical therapy.

Less than High School
type: Class
type: QualityValue
notation: 215
subclass of: High School or Less

mono-2-ethyl-5- carboxypentyl terephthalate (DEHTP)
notation: MECPTP

Hospitalization
subclass of: Hospital Utilization
type: QualityValue
notation: 104
subclass of: SIO_001024
type: Class
definition: Admission to a hospital

N-Acetyl-S-(benzyl)-L-cysteine(ng/mL)
notation: VOCBMA
subclass of: Volatile Organic Compound
type: Class
editorial note: To Do: align with CHEBI.

Lipemic sample, clarified before running
subclass of: SIO_001167
type: Class

4, 4'-DDE
type: Class
notation: PPDDE
subclass of: Organochlorine Compound

cubic centimeter per mole
type: SIO_000074
notation: cm3/mol

Relative Time
type: Class
definition: A time in relation to an event
subclass of: SIO_000391
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Process

Infinium Methylation EPIC BeadChip Assay
subclass of: Microarray Assay
type: Class
subclass of: Methylation Assay

Human Dwelling
definition: Any enclosed space that may be considered a human residence, considered broadly. Positive examples include Moble Homes, Single Family Homes, Apartment Buildings, Cars, Garages, Campgrounds, etc.
type: QualityVariable
subclass of: Housing Characteristic
type: Class

kilogram per meter
notation: kg/m
type: SIO_000074

diethylthiophosphate
subclass of: Alkyl Phosphate Pesticide Metabolite
type: Class
editorial note: To Do: align with CHEBI.
notation: DETP

Difference of Z-Scores
subclass of: Restriction
  on property: SIO hasAttribute
  some values from: Class
    intersection of: Subtrahend
    intersection of: Z-Score
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Z-Score
  on property: SIO hasAttribute
type: Class
definition: The arithmetic difference of two Z-Scores

microsievert
notation: µSv
type: SIO_000074

Early Childhood Vigilance Test
type: Class
subclass of: Neurocognitive Assessment
definition: a computer-based assessment of sustained attention during which the child is required to watch a screen where various animated stimuli disappear and reappear

N-Acetyl-S-(2, 4-dimethylphenyl)-L-cysteine + N-Acetyl-S-(2, 5-dimethylphenyl)-L-cysteine + N-Acetyl-S-(3, 4-dimethylphenyl)-L-cysteine
notation: DPMA
editorial note: To Do: align with CHEBI.
subclass of: Volatile Organic Compound
type: Class

picomolal
notation: pmolal
type: SIO_000074

Adolescent Period
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing
definition: The age span ranging from adolescence to adulthood

Asthma Controller Use
subclass of: Restriction
  on property: SIO_000291
  some values from: SIO_000393
type: Class
equivalent class:
  union of: Has taken asthma control medications
  union of: Never takes asthma control medications
type: QualityVariable
subclass of: Restriction
  on property: SIO_000230
  some values from: Asthma Controller Medication
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
definition: A subclass of medical intervention in which a patient takes an asthma controller medication.

Health Outcome
type: Class
subclass of: StudyIndicator

Annulled
subclass of: Never Married
type: Class
definition: A marital status in which a voidable marriage is legally declared null and void, as though it never existed. Specific grounds for annullment vary within the presiding jurisdiction, whether geographic or religious.
notation: 43
type: QualityValue

Prescription Medication and Dietary Supplements
type: Class
definition: Prescription Medication and Dietary Supplements are forms of medical treatment.
was approved by: PER-Jeanette-Stingone
subclass of: StudyIndicator

N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine
type: Class
notation: GAMA
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.

Childhood Baseline
definition: A point in a study set to the initial point which occurs during the study subject's childhood period.
subclass of: SIO_000417
type: Class
subclass of: Study Baseline
subclass of: Restriction
  all values from: Class
    intersection of: Childhood Period
  on property: inRelationTo

Landfill Proximity
type: QuantityVariable
definition: How close a household is to a landfill.
subclass of: Environmental Exposure
subclass of: SIO_000041
type: Class
was approved by: PER-Jeanette-Stingone

Targeted Analyte
was approved by: PER-Jeanette-Stingone
subclass of: StudyIndicator
definition: A targeted analyte is one that has been selected by the CHEAR program as a prioritized analyte for CHEAR lab hubs to measure and has been carried over to HHEAR.
type: Class
subclass of: Analyte

Perfluorooctanesulfonate
notation: PFDODA
subclass of: PFC
type: Class

Education Grade 1
notation: 113
subclass of: Some Elementary School
type: QualityValue
type: Class
definition: Finished grade 1

High Performance Liquid Chromatography
subclass of: Chromatography
type: Class

eosinophilic esophagitis
type: Class
subclass of: esophageal disease

Height
definition: Height
was approved by: PER-Jeanette-Stingone
subclass of: Anthropometry
type: QuantityVariable
type: Class

cigarettes per day
subclass of: Alcohol, Tobacco, and Illicit Drug Use
type: QualityValue
type: Class
notation: 152

nanovolt
notation: nV
type: SIO_000074

Transfer
subclass of: Destination
type: Class
notation: 172
type: QualityValue
definition: The act of conveying or transporting from one place to another.

SYNAPT G2-Si Mass Spectrometer
subclass of: Hydrogen–Deuterium Exchange Mass Spectrometer
was approved by: PER-Jim-McCusker
type: Class

Interstitial collagenase
subclass of: Protein
notation: MMP1
type: Class

Titanium
type: Class
notation: Ti
subclass of: Metal
definition: TITANIUM is a dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)

2, 3, 4, 5-Tetrachlorophenol
subclass of: Environmental Phenol
type: Class
definition: PHYSICAL DESCRIPTION: Needles (from petroleum ether, ligroin) or beige solid. (NTP, 1992)
notation: TeCP2345

Parent
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: Ancestor
definition: A parent is the caretaker of a child (where "child" refers to offspring, not necessarily age). A biological parent is a person whose gamete resulted in a child, a male through the sperm, and a female through the ovum. Parents are first-degree relatives and have 50% genetic meet. A female can also become a parent through surrogacy. Some parents may be adoptive parents, who nurture and raise an offspring, but are not actually biologically related to the child. Orphans without adoptive parents can be raised by their grandparents or other family members.
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Child
    intersection of: SIO_000485

Specimen analyzed with less than usual dilution
type: Class
subclass of: SIO_001167

Mother
definition: A mother is the female parent of a child. Mothers are women who inhabit or perform the role of bearing some relation to their children, who may or may not be their biological offspring. Thus, dependent on the context, women can be considered mothers by virtue of having given birth, by raising their child(ren), supplying their ovum for fertilisation, or some combination thereof. Such conditions provide a way of delineating the concept of motherhood, or the state of being a mother. Women who meet the third and first categories usually fall under the terms 'birth mother' or 'biological mother', regardless of whether the individual in question goes on to parent their child. Accordingly, a woman who meets only the second condition may be considered an adoptive mother, and those who meet only the third a surrogacy mother. The above concepts defining the role of mother are neither exhaustive nor universal, as any definition of 'mother' may differ based on how social, cultural, and religious roles are defined.
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010052
    on property: hasAttribute
type: Class
type: QualityValue
was approved by: PER-Jeanette-Stingone
notation: 189
subclass of: Parent

Income 15000 to 29999
notation: 220
type: Class
subclass of: Household Income
type: QualityValue

Liquid Chromatography–Mass Spectrometer
was approved by: PER-Jim-McCusker
type: Class
subclass of: Mass Spectrometer
subclass of: Liquid Chromatography Instrument
definition: An analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin.

Barium
subclass of: Metal
definition: BARIUM is an element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.
notation: Ba
type: Class

Laboratory Result
type: Class
definition: A measurement taken on a sample.
subclass of: Indicator

Age Equivalent
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
definition: Age Equivalent is the individual's ability; skill, knowledge, or measurement expressed as the age at which most individuals reach the same level (age norm). The Age Norm is the average score of a particular test completed by children of a given chronological age.
subclass of: STATO_0000569

Born Third
type: Class
type: QualityValue
definition: The third born child
subclass of: NCIT C25260
subclass of: Birth Order
notation: 238

Quit Smoking After Pregnancy
definition: Quit Smoking After Pregnancy
notation: 80
subclass of: Quit Smoking
type: Class
subclass of: Prenatal Smoker
type: QualityValue
subclass of: Pregnancy Characteristic

Attribute
type: Class
subclass of: ScienceIndicator

Several times a month exposure to second hand smoke from E-cigarettes
type: Class
type: QualityValue
notation: 257
subclass of: environmental e-cigarette smoke exposure

2, 2', 4, 4', 5, 6'-Hexabromodiphenyl ether
subclass of: Polybrominated Diphenyl Ether
notation: BDE154
editorial note: To Do: align with CHEBI.
type: Class

First Trimester
subclass of: SIO_000417
subclass of: From Conception
was approved by: PER-Jeanette-Stingone
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
type: Class
definition: From pregnancy week 1 through 12 and includes conception. Conception is when the sperm fertilizes the egg. The fertilized egg then travels down the fallopian tube and attaches to the inside of the uterus, where it begins to form the embryo and placenta. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus).

Adulthood Period
definition: Time period that begins after adolesence and continues until death
type: Class
subclass of: From Birth

centiMorgan
type: SIO_000074
notation: cM

millisecond
type: SIO_000074
notation: ms

Ultra-Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Ultra Performance Liquid Chromatography - Mass Spectrometer
was approved by: PER-Jim-McCusker
subclass of: Tandem Mass Spectrometer

Mercury
notation: Hg
subclass of: Metal
definition: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
type: Class

Value below LLOQ, no LOD provided
subclass of: SIO_001167
type: Class

6-hydroxychrysene
type: Class
notation: CHRY6
subclass of: PAH

Income 25,000 to 34,999
type: QualityValue
notation: 267
subclass of: Income 20001 to 40000
subclass of: Household Income
type: Class

Occasional E-Cigarette Use
type: Class
type: QualityValue
subclass of: E-Cigarette Use
notation: 155

Insurance Type
definition: Insurance Type
type: Class
subclass of: Insurance
type: QualityVariable

alpha-hexachlorocyclohexane
notation: AHCH
type: Class
subclass of: Organochlorine Compound

PCB118
notation: PCB118
type: Class
subclass of: Polychlorobiphenyl

Diet
type: QualityVariable
definition: The customary allowance of food and drink taken by a person or an animal from day to day, particularly one especially planned to meet specific requirements of the individual, including or excluding certain items of food; a prescribed course of eating and drinking in which the amount and kind of food, as well as the times at which it is to be taken, are regulated for therapeutic purposes or selected with reference to a particular state of health.
subclass of: Diet and Nutrition
type: Class

Income 5000 or Less
subclass of: Income 14999 or Less
subclass of: Household Income
definition: Personal or family annual income at or below $5,000
notation: 159
type: Class
type: QualityValue

Hemoglobin
subclass of: Protein
was approved by: PER-Jim-McCusker
type: Class
definition: The iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae), as well as the tissues of some invertebrates. Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism.

Tobacco Cessation Intervention Group
definition: A group receiving a tobacco cessation intervention that is being tested in a study.
subclass of: Experimental Group
notation: 202
type: Class
type: QualityValue

2-amnothiazolne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCATC

Benzophenone-3
type: Class
subclass of: Environmental Phenol
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
notation: BP3
editorial note: Duplicate of OXB?

Maternal Weight Gain
was approved by: PER-Jeanette-Stingone
subclass of: Weight
type: Class
subclass of: Pregnancy Characteristic
definition: The amount of weight gained during a pregnacy.

Race
type: Class
subclass of: Race or Ethnicity Combined
subclass of: Demographic
type: QualityVariable
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000475

Circumference
subclass of: Anthropometry
type: Class
type: QuantityVariable

Value above LOD but below LLOQ
subclass of: SIO_001167
type: Class

(15Z)-tetracosenoic acid
definition: A tetracosenoic acid having a cis-double bond at position 15.
subclass of: Fatty Acid
notation: C241N9
type: Class

3-phenoxybenzoic acid
notation: PBA
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
type: Class

Trunk
definition: Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.
type: Class
subclass of: SIO_010046

katal per cubic meter
notation: kat/m3
type: SIO_000074

Other Material Finish
notation: 70
type: Class
type: QualityValue
definition: Flooring is made from another unspecified material.
subclass of: Floor Type
was approved by: PER-Jeanette-Stingone

3-hydroxyphenanthrene
subclass of: PAH
notation: PHEN3
type: Class

Bisphenol S
subclass of: Environmental Phenol
type: Class
notation: BPS

Normal Weight
subclass of: Restriction
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        on property: STATO_0000129
        some values from: Datatype
  on property: isAttributeOf
subclass of: Underweight/Normal
definition: 18.5<=BMI<=25
type: QualityValue
notation: 61
type: Class
subclass of: Body Weight Quality

Ethnicity
subclass of: Race or Ethnicity Combined
type: QualityVariable
subclass of: Demographic
type: Class
subclass of: SIO_000475
was approved by: PER-Jeanette-Stingone

2, 2', 3, 4, 4', 5', 6-Heptabromodiphenyl ether
notation: BDE183
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Polybrominated Diphenyl Ether

Microplate Reader
was approved by: PER-Jim-McCusker
type: Class
subclass of: PhysicalInstrument
definition: Instruments which are used to detect biological, chemical or physical events of samples in microtiter plates. They are widely used in research, drug discovery, bioassay validation, quality control and manufacturing processes in the pharmaceutical and biotechnological industry and academic organizations. Sample reactions can be assayed in 6-1536 well format microtiter plates. The most common microplate format used in academic research laboratories or clinical diagnostic laboratories is 96-well (8 by 12 matrix) with a typical reaction volume between 100 and 200 µL per well. Higher density microplates (384- or 1536-well microplates) are typically used for screening applications, when throughput (number of samples per day processed) and assay cost per sample become critical parameters, with a typical assay volume between 5 and 50 µL per well. Common detection modes for microplate assays are absorbance, fluorescence intensity, luminescence, time-resolved fluorescence, and fluorescence polarization.

Native Hawaiian or Other Pacific Islander
was approved by: PER-Jeanette-Stingone
definition: A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands.
subclass of: Non-White
notation: 55
subclass of: Race
type: Class
type: QualityValue

Tooth
subclass of: Tissue
type: Class
definition: Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Tooth_(animal)]

6-chloronicotinic acid
notation: CINA6

Mass Spectrometer
definition: Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.
subclass of: PhysicalInstrument
type: Class
was approved by: PER-Jim-McCusker

milligrams-microunits per deciliter-milliliter
type: SIO_000074
notation: (mg/dL)*(µU/mL)

Unemployment
subclass of: Occupation
type: Class
notation: 67
definition: The state of not having a job.
type: QualityValue

Specific Gravity
subclass of: SIO_001018
editorial note: Why is this here? Maybe it belongs in another list
type: Class
subclass of: Targeted Analyte
definition: Specific gravity is the ratio of the density of a substance to the density of a reference substance; equivalently, it is the ratio of the mass of a substance to the mass of a reference substance for the same given volume. Apparent specific gravity is the ratio of the weight of a volume of the substance to the weight of an equal volume of the reference substance. The reference substance is nearly always water at its densest (4°C) for liquids; for gases it is air at room temperature (21°C). Nonetheless, the temperature and pressure must be specified for both the sample and the reference. Pressure is nearly always 1 atm (101.325 kPa). Temperatures for both sample and reference vary from industry to industry.
type: QuantityVariable

Process
subclass of: ScienceIndicator
type: Class

Overweight
type: Class
type: QualityValue
notation: 71
subclass of: Restriction
  on property: isAttributeOf
  some values from: Restriction
    on property: hasAttribute
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
subclass of: Body Weight Quality

Benzyl paraben
notation: BzPB
subclass of: Paraben
type: Class
definition: Benzylparaben is a Standardized Chemical Allergen. The physiologic effect of benzylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of benzylparaben is Allergens.

pneumonia
notation: 195
type: Class
type: QualityValue
subclass of: DOID 850

Takes asthma control medications some days but not others
notation: 277
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Takes some days but not others
  on property: SIO_000217

Developmental Quality
type: QualityVariable
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000475
definition: Refers to which stage of development a person is in.
type: Class

SIO_010052
notation: 110
type: QualityValue

mono-(2-ethyl-5-carboxypentyl) phthalate
subclass of: Phthalate
editorial note: Duplicate of MCEPP?
notation: mECPP
type: Class

Only takes asthma control medications with symptoms
type: QualityValue
notation: 275
subclass of: Has taken asthma control medications
subclass of: Restriction
  some values from: Only takes with symptoms
  on property: SIO_000217
subclass of: Asthma Controller Use
type: Class

Zafirlukast (Accolate)
type: Class
subclass of: Asthma Controller Medication

eosinophils per high-power field
subclass of: SIO_000794
type: Class
comment: A histological count of the eosinophils in a high-power microscopic field of view, or 0.158 mm^2 (x400).

Prenatal Smoker
notation: 77
subclass of: Smoker
editorial note: Should this be a subClassOf PregnancyCharactistic as well?
type: QualityValue
definition: The quality of having smoked while being pregnant.
type: Class

Daily Smoker
type: QualityValue
notation: 157
subclass of: Smoking Status
type: Class

FEV1 Predicted Value
subclass of: CMO_0000254
type: Class
type: QualityVariable
definition: The expected or predicted FEV1 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Z-Score
type: Class
definition: A z-score (also known as z-value, standard score, or normal score) is a measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value.
subclass of: Anthropometry

Multi-Family House
definition: A residential building designed to hold more than one family.
type: QualityValue
type: Class
notation: 176
subclass of: Residential Building

Fast Food Consumption Frequency
type: Class
definition: Frequency of Fast Food Consumption.
was approved by: PER-Jeanette-Stingone
subclass of: Diet Quantity
type: QuantityVariable

SIO_000981
type: QualityValue
notation: 108

decibel
type: SIO_000074
notation: dB

Personal Product Use
definition: Personal Product Use Indicator Class
type: Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone

Weight
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: SIO_000279
type: QuantityVariable
definition: The resulting Force from the interaction between a person's Mass and Gravity.
subclass of: Anthropometry

Subject
definition: A living individual about whom a research investigator (whether a professional or a student) obtains data through 1) intervention or interaction with the individual, or 2) identifiable private information
subclass of: SIO_000016
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Study
  on property: inRelationTo

3, 5, 6-trichloro-2-pyridinol
notation: TCP
subclass of: Alkyl Phosphate Pesticide Metabolite
type: Class
editorial note: To Do: align with CHEBI.

Strontium
type: Class
definition: STRONTIUM is an element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.
notation: Sr
subclass of: Metal

From Birth
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: birthing
  on property: inRelationTo
subclass of: Relative Time
definition: A time in relation to a birth

Creatinine
notation: CRE
type: Class
subclass of: Targeted Analyte
definition: Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

Cement Floor
type: Class
definition: Cement Floor Type
type: QualityValue
notation: 10
was approved by: PER-Jeanette-Stingone
subclass of: Floor Type

2-Aminothiazoline-4-carboxylic acid
notation: ATCA
editorial note: To Do: align with CHEBI.
subclass of: Volatile Organic Compound
type: Class

FEV1 Best Value
subclass of: CMO_0000254
type: QualityVariable
definition: The best FEV1 value achieved by a subject during a series of FEV1 measurements.
type: Class

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
notation: VOCPHE
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class

degree Fahrenheit
notation: F
type: SIO_000074

Income 5001 to 10000
type: Class
subclass of: Income 14999 or Less
subclass of: Household Income
notation: 204
subclass of: Income 5001 to 15000
type: QualityValue

gigabyte
notation: GB
type: SIO_000074

picomole
type: SIO_000074
notation: pmol

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCMB3

Birth Cohort Study
type: Class
subclass of: CohortStudy

Unusually high
subclass of: SIO_001167
type: Class

2-hydroxyphenanthrene
type: Class
notation: PHEN2
subclass of: PAH

Chromatography Instrument
type: Class
definition: Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate. The separation is based on differential partitioning between the mobile and stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation.
subclass of: PhysicalInstrument
was approved by: PER-Jim-McCusker

Did Not Consume Alcohol
notation: 53
subclass of: Alcohol Use
type: Class
type: QualityValue

count per molar
type: SIO_000074
notation: 1/M

Value greater than ULOQ
subclass of: SIO_001167
type: Class

N-Acetyl-S-(2-cyanoethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: CYMA
editorial note: To Do: align with CHEBI.

Gravida
was approved by: PER-Jeanette-Stingone
definition: Pregnancy Count, regardless of whether pregnancy was carried to Term.
type: QuantityVariable
type: Class
subclass of: SIO_000794
subclass of: Pregnancy Characteristic

mono-benzyl phthalate
editorial note: Is this a repeat of MBP?
subclass of: Phthalate
notation: mBzP
type: Class

Medical History
definition: Medical History Indicator Class
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: StudyIndicator

Technical Post Primary School
type: QualityValue
subclass of: High School or Less
was approved by: PER-Jeanette-Stingone
notation: 95
definition: Attended a Technical Post Primary School
type: Class
subclass of: Technical School

2-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MHA2

cyclic peptide
type: Class
subclass of: Metabolite
subclass of: Biological Response
definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).

minute
type: SIO_000074
notation: min

Gel Electrophoresis
subclass of: SIO_001007
type: Class
definition: Gel electrophoresis is a method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge.

billion parts per microgram
type: SIO_000074
notation: x109 µL

Limit of Quantitation
type: Class
subclass of: Concentration
definition: The Limit of Quantitation is the lowest concentration at which the analyte can not only be reliably detected but at which some predefined goals for bias and imprecision are met. The LoQ may be equivalent to the LoD or it could be at a much higher concentration. (Source: Limit of Blank, Limit of Detection and Limit of Quantitation, David A Armbruster and Terry Pry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556583/)

4, 4'-(1-phenylethylidene)bisphenol
notation: BPAP

Renter
type: Class
type: QualityValue
definition: This person rents the home they live in.
subclass of: Home Ownership
notation: 148

2, 4, 4'-Tribromodiphenyl ether
type: Class
editorial note: To Do: align with CHEBI.
notation: BDE28
subclass of: Polybrominated Diphenyl Ether

Insurance
type: Class
subclass of: Healthcare Access
type: QualityVariable
subclass of: Socioeconomic Status

Income 75001 to 90000
subclass of: Income 50000 to 99999
type: Class
definition: Personal or family annual income bwtween $75,001 and $90,000
type: QualityValue
notation: 164
subclass of: Income more than 70001
subclass of: Household Income

Alcohol, Tobacco, and Illicit Drug Use
subclass of: StudyIndicator
definition: Alcohol, Tobacco, and Illicit Drug Use Indicator Class
was approved by: PER-Jeanette-Stingone
type: Class

2-thoxothazlidne-4-carbxylic acid(ng/mL)
notation: VOCTTC
editorial note: To Do: align with CHEBI.
subclass of: Volatile Organic Compound
type: Class

absorbance unit
type: SIO_000074
notation: AU

SIO_000982
type: QualityValue
notation: 106

octadecanoic acid
type: Class
definition: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.
subclass of: Fatty Acid
notation: C180

Advanced Graduate Degree
type: Class
definition: Having earned a pos-baccalaureate degree
type: QualityValue
subclass of: Education
notation: 4

5-10 Residence Building
definition: A residential building that contains between five and ten apartments, town houses, condos, or other single family dwelling spaces.
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 233

Acculturation
type: Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone
definition: Acculturation explains the process of cultural change and psychological change that results following meeting between cultures. This metaclass contains all classes that measure this process.

2, 2', 3, 3', 4, 4', 5, 5', 6, 6'-Decabromodiphenyl ether
type: Class
editorial note: To Do: align with CHEBI.
notation: BDE209
subclass of: Polybrominated Diphenyl Ether

international units per litre
type: SIO_000074
notation: IU/L

Interleukin-8
notation: IL8
type: Class
subclass of: Biological Response

Partial match
type: Class
subclass of: SIO_001167

Some Middle School
definition: Attended Some Middle School
subclass of: High School or Less
type: Class
notation: 90
was approved by: PER-Jeanette-Stingone
type: QualityValue

milliliter per cubic meter
type: SIO_000074
notation: ml/m3

Beclomethasone HFA
subclass of: Asthma Controller Medication
type: Class

cells per microliter
type: SIO_000074
notation: cp/µl

Spontaneous Preterm Birth
notation: 91
type: Class
subclass of: Preterm Birth
type: QualityValue

attomole
notation: amol
type: SIO_000074

Bathroom Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable
definition: Total Number of Bathrooms in the Home
subclass of: Room Count
type: Class

2, 2', 4, 4', 5, 5'-Hexabromodiphenyl ether
subclass of: Polybrominated Diphenyl Ether
type: Class
editorial note: To Do: align with CHEBI.
notation: BDE153

milligram per deciliter
notation: mg/dl
type: SIO_000074

Ever Smoked
was approved by: PER-Jeanette-Stingone
notation: 136
type: QualityValue
subclass of: Smoking Status
type: Class
definition: The quality of having smoking in the past.

Non-White Hispanic
notation: 146
subclass of: Non-White
type: Class
definition: Non-White and Hispanic
type: QualityValue
subclass of: Hispanic or Latino Ethnicity

2, 2', 4'-Tribromodiphenyl ether
type: Class
editorial note: To Do: align with CHEBI.
subclass of: Polybrominated Diphenyl Ether
notation: BDE17

PCB28
subclass of: Polychlorobiphenyl
notation: PCB28
type: Class

Fibrinogen Assay (Clauss method)
type: Class
subclass of: SIO_001007

Leptin
type: Class
definition: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.
subclass of: Protein
subclass of: Metabolite

Pregnancy Characteristic
definition: Pregnancy Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone
subclass of: StudyIndicator
type: Class

Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
type: Class
definition: When a sperm fertilizes an egg
was approved by: PER-Jeanette-Stingone
subclass of: Beginning
subclass of: From Conception
subclass of: SIO_000417

percent
notation: %
type: SIO_000074

Parental Health and Family History
type: Class
definition: Parental Health and Family History Indicator Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone

Dilution required
subclass of: SIO_001167
type: Class

mono ethyl hexyl phthalate
notation: MEHP
subclass of: Phthalate
type: Class
definition: PHYSICAL DESCRIPTION: Clear colorless to cloudy white viscous liquid. (NTP, 1992)

millivolt
notation: mV
type: SIO_000074

Occasional Smoker
notation: 158
type: Class
subclass of: Smoking Status
type: QualityValue

Before
definition: A negative index of a time measurement in relation to a reference event. A conventional time measurement can be generated from a before time measurement by duplicating the measurement, reversing the sign of the value, and removing the "Before" class.
type: Class
subclass of: Relative Time

Boiler Count
type: Class
definition: A boiler is an object that heats up water. This attribute quantifies the number of boilers in the home.
type: QuantityVariable
was approved by: PER-Jeanette-Stingone
subclass of: Household Appliance Count

mono-pentyl phthalate
subclass of: Phthalate
type: Class
notation: mPeP

Assisted Reproductive Therapy
type: QualityValue
subclass of: Pregnancy Characteristic
type: Class
notation: 7

p-Xylene*
definition: P-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. Freezing point is 56°F. (USCG, 1999)
subclass of: Volatile Organic Compound
type: Class
notation: PXY

VCR Player Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable
definition: Number of devices that play VCRs in the home.
type: Class
subclass of: Household Appliance Count

N-Ace-S-(2-hydroxypropyl)-L-cys(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCHP2
type: Class
subclass of: Volatile Organic Compound

DVD Player Count
subclass of: Household Appliance Count
was approved by: PER-Jeanette-Stingone
definition: Number of devices in the home that play DVDs.
type: Class
type: QuantityVariable

Mean Concentration
type: QuantityVariable
subclass of: SIO_001109
subclass of: Concentration
type: Class
definition: The mean aggregate of multiple concentration measurements of a single substance within a compound substance.

N-Acetyl-S-(phenyl)-L-cysteine
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: PMA

N-Ace-S-(2-Hydroxyethyl)-L-cys(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCHEM
subclass of: Volatile Organic Compound
type: Class

gamma-hexachlorocyclohexane
subclass of: Organochlorine Compound
type: Class
notation: GHCH

degree Celsius
type: SIO_000074
notation: C

Education Grade 7
definition: Finished grade 7
notation: 119
type: Class
type: QualityValue
subclass of: Some Middle School

Other GI Disease
subclass of: SIO_010299
type: QualityValue
type: Class
editorial note: This is a temp concept that needs addressing
notation: 69
subclass of: Health Outcome

ampere
notation: A
type: SIO_000074

Black Non-Hispanic
type: QualityValue
subclass of: Non-Hispanic Ethnicity
type: Class
subclass of: African American
notation: 216

all-cis-icosa-8, 11, 14-trienoic acid
subclass of: Fatty Acid
definition: An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.
notation: C203N6
type: Class

Theophylline
type: Class
subclass of: Asthma Controller Medication

Unplanned Caesarian Section
subclass of: Caesarian Section
definition: Had an unplanned caesarian section.
type: QualityValue
type: Class
notation: 23
was approved by: PER-Jeanette-Stingone

Cellular debris present
subclass of: SIO_001167
type: Class

Vacuum Cleaner Count
was approved by: PER-Jeanette-Stingone
definition: Number of appliances in home used for cleaning rugs.
subclass of: Household Appliance Count
type: QuantityVariable
type: Class

Multiplex real-time PCR
subclass of: Polymerase Chain Reaction
type: Class

Nornicotine
notation: NORN
type: Class
subclass of: Tobacco Metabolite

Income 90001 to 120000
subclass of: Household Income
type: Class
type: QualityValue
notation: 165
definition: Personal or family annual income bwtween $90,001 and $120,000
subclass of: Income more than 70001

Floor Type
was approved by: PER-Jeanette-Stingone
type: QualityVariable
subclass of: SIO_000004
subclass of: Housing Characteristic
type: Class
definition: Type of material that makes up the floor.

2, 4'-DDT
notation: OPDDT
subclass of: Organochlorine Compound
type: Class

Haircare Product Use
type: Class
subclass of: Personal Product Use
notation: 30
type: QualityValue
was approved by: PER-Jeanette-Stingone

mild eosinophilic esophagitis
type: Class
equivalent class: Restriction
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
  on property: isPhenotypeOf
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is mild when a biopsy of the esophagus reveals a count of 15-25 eosinophils per high-power field area, or 0.158 mm^2 (400x).

turns per second
type: SIO_000074
notation: 1/s

nanosievert
notation: nSv
type: SIO_000074

Never takes
type: Class
subclass of: SIO_001289

Gas Chromatographer–Mass Spectrometer
subclass of: Mass Spectrometer
definition: Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification. Like liquid chromatography–mass spectrometry, it allows analysis and detection even of tiny amounts of a substance.
subclass of: Gas Chromatography Instrument
was approved by: PER-Jim-McCusker
type: Class

High-Performance Liquid Chromatography
was approved by: PER-Jim-McCusker
type: Class
subclass of: Liquid Chromatography Instrument
definition: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out the column.

Meconium
subclass of: Pregnancy Sample
definition: A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth. [database_cross_reference: BTO:0000838]
type: Class
subclass of: Feces

Nicotine-N-oxide
notation: NICO
subclass of: Tobacco Metabolite
type: Class

Volatile Organic Compound
type: Class
subclass of: Targeted Analyte

Arsenic
notation: As
type: Class
definition: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
subclass of: Metal

Teenager
subclass of: Developmental Quality
was approved by: PER-Jeanette-Stingone
subclass of: Demographic
definition: An individual between the ages of 13 and 19.
type: QualityValue
type: Class
notation: 137

Rarely exposed to second hand smoke from E-cigarettes
subclass of: environmental e-cigarette smoke exposure
type: QualityValue
notation: 258
type: Class

Son
definition: A son is a male offspring; a boy or man in relation to his parents.
subclass of: Child
subclass of: Restriction
  all values from: Restriction
    some values from: SIO_010048
    on property: hasAttribute
  on property: isRoleOf
type: Class

2, 2'-dihydroxy-methoxybenzophenone
notation: BP8

Spontaneous Caesarian Section
notation: 22
definition: Had a spontaneous caesarian section
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: Caesarian Section
type: QualityValue

Cotinine (total)
subclass of: Tobacco Metabolite
type: Class
notation: COTT
editorial note: To Do: align with CHEBI.

Residential Building
type: QualityVariable
subclass of: Housing Characteristic
type: QualityValue
type: Class
notation: 154

Language
type: Class
subclass of: Acculturation
editorial note: Needs to be rooted in sio
type: QualityVariable

Income 40001 to 70000
type: QualityValue
type: Class
notation: 207
subclass of: Household Income

Malaria
type: Class
subclass of: SIO_010299
subclass of: Health Outcome
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.
type: QualityValue
notation: 121

cell in vitro
type: Class
subclass of: Cell

Gestational Age at Birth
type: Class
subclass of: Gestational Age
definition: Describes how far along a pregnancy is, usually measured in weeks, as measured at birth.
equivalent class: Class
  intersection of: Gestational Age
  intersection of: Restriction
    on property: measuredAt
    all values from: Birth

Neurocognitive Assessment
type: Class
subclass of: Physical And Mental Assessment

Body Mass Index
subclass of: Class
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Height
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: SIO_000279
type: Class
subclass of: Anthropometry
type: QuantityVariable
definition: A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length
editorial note: Should we note that this is derived from height and weight? JS: I think so
subclass of: SIO_000052
was approved by: PER-Jeanette-Stingone

Several times a month exposure to second hand smoke
type: QualityValue
notation: 252
type: Class
subclass of: environmental tobacco smoke exposure

Birth Outcome
subclass of: StudyIndicator
definition: Birth Outcomes Indicator Class
was approved by: PER-Jeanette-Stingone
type: Class

mono (6-COOH-2-methylheptyl) phthalate
notation: MCOMHP
subclass of: Phthalate
type: Class

Education Grade 5
notation: 117
subclass of: Some Middle School
definition: Finished grade 5
type: QualityValue
type: Class

Molybdenum
notation: Mo
subclass of: Metal
type: Class
definition: MOLYBDENUM is a metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)

Budesonide DPI (Pulmicort)
subclass of: Asthma Controller Medication
type: Class

tetradecanoic acid
notation: C140
definition: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.
type: Class
subclass of: Fatty Acid

picogram per milliliter
notation: pg/mL
type: SIO_000074

Active Non-Tobacco Smoker
type: QualityValue
subclass of: Active Smoker
notation: 1
type: Class
definition: Active Non-Tobacco Smoker

Anatabine
type: Class
notation: ANAT
subclass of: Tobacco Metabolite

Mental Health
definition: Mental Health Indicator
subclass of: Physical And Mental Assessment
was approved by: PER-Jeanette-Stingone
type: Class

C-reactive protein
subclass of: Protein
definition: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
type: Class

Route Of Delivery
type: QualityVariable
type: Class
subclass of: Delivery Characteristics

Head of Household
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Household
  on property: inRelationTo
subclass of: SIO_000016
was approved by: PER-Jeanette-Stingone
subclass of: Demographic
definition: The Person is the head of Household
definition: Head of Household is a filing status for individual United States taxpayers. To use the Head of Household filing status, a taxpayer must: (1) Be unmarried or considered unmarried at the end of the year (2) Have paid more than half the cost of keeping up a home for the tax year (either one's own home or the home of a qualifying parent) (3) Usually have a qualifying person who lived with the head in the home for more than half of the tax year unless the qualifying person is a dependent parent.
label: Head Of Household

Born Fourth
definition: The fourth born child
notation: 239
subclass of: Birth Order
subclass of: NCIT C54566
type: QualityValue
type: Class

Hair
subclass of: Tissue
definition: A filament, mostly protein, that grows from follicles found in the dermis[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Hair]
type: Class

Obese
type: Class
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: hasAttribute
  on property: isAttributeOf
subclass of: Body Weight Quality
type: QualityValue
notation: 63

Oral Health
type: Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone
definition: Oral Health Indicator Class

micromole per liter
notation: µmol/L
type: SIO_000074

Doctorate Degree
notation: 144
subclass of: Some Postgraduate
type: QualityValue
definition: The Doctor's Degree is the highest award a student can earn for graduate study. The doctor's degree classification includes such degrees in any field.
type: Class
subclass of: Higher Education

mono-carboxy isononyl phthalate
type: Class
subclass of: Phthalate
notation: mCINP

2, 2', 4, 4'-tetrahydroxybenzophenone
notation: BP2

micrometer
type: SIO_000074
notation: µm

mono-carboxy isooctyl phthalate
type: Class
notation: mCIOP
subclass of: Phthalate

Ruthenium
subclass of: Metal
type: Class
notation: Ru
definition: RUTHENIUM is a hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.

Phenotype
type: Class
subclass of: Health Outcome

environmental e-cigarette smoke exposure
type: QualityVariable
definition: Exposure to secondhand smoke via e-cigarettes
type: Class
subclass of: Alcohol, Tobacco, and Illicit Drug Use

mono benzyl phthalate (BzBP)
subclass of: Phthalate
type: Class
notation: MBP

Prenatal Vitamin Use
notation: 149
subclass of: MAXO_00001018
type: Class
type: QualityValue
definition: Prenatal vitamins are supplements that contain daily vitamins and minerals needed by mothers before and during pregnancy.

Never exposed to second hand smoke from E-cigarettes
notation: 259
subclass of: environmental e-cigarette smoke exposure
type: Class
type: QualityValue

Perfume Use
notation: 74
type: QualityValue
subclass of: Personal Product Use
type: Class
was approved by: PER-Jeanette-Stingone

Fast Food Consumption
definition: Whether or not fast food is consumed.
type: QualityValue
notation: 16
subclass of: Fast Food Consumption Frequency
type: Class
was approved by: PER-Jeanette-Stingone

hypertension
subclass of: DOID_0050828
type: Class
type: QualityValue
notation: 178

Technical Post-Middle School
notation: 94
subclass of: Technical School
definition: Attended a Technical Post-Middle School.
type: QualityValue
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: High School or Less

katal per liter
type: SIO_000074
notation: kat/l

Father
subclass of: Parent
notation: 188
type: QualityValue
type: Class
subclass of: Restriction
  all values from: Restriction
    some values from: SIO_010048
    on property: hasAttribute
  on property: isRoleOf
definition: The male parent of a child. Besides the paternal bonds of a father to his children, the father may have a parental legal and social relationship with the child that carries with it certain rights and obligations. An adoptive father is a male who has become the child's parent through the legal process of adoption. A biological father is the male genetic contributor to the creation of the baby, through sexual intercourse or sperm donation. A biological father may have legal obligations to a child not raised by him, such as an obligation of monetary support. A putative father is a man whose biological relationship to a child is alleged but has not been established. A stepfather is a male who is the husband of a child's mother and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child.
was approved by: PER-Jeanette-Stingone

Outdoor Air
subclass of: ENVO_00002005
type: QualityVariable
subclass of: Restriction
  some values from: ExO_0000020
  on property: SIO_000128
type: Class

Environmental Phenol
type: Class
subclass of: Targeted Analyte

Subtrahend
type: Class
definition: In a difference expression, the subtrahend is the quantity or number to be subtracted from another.
subclass of: SIO_000052
type: QuantityVariable

wheezing or tightness in the chest or cough
type: QuantityVariable
subclass of: Physical And Mental Assessment
type: Class
subclass of: HP_0000118

Metal
definition: For environmental purposes, HHEAR metals are metals and metalliods, as originally defined in CHEAR.
subclass of: Element
type: Class

Reproductive Health
subclass of: StudyIndicator
type: Class
was approved by: PER-Jeanette-Stingone
definition: Reproductive Health Indicator Class

Retina
definition: The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
type: Class
subclass of: SIO_010003

Sandwich ELISA
definition: Sandwich ELISAs involve attachment of a capture antibody to a solid phase support. Samples containing known or unknown antigen are then added in a matrix or buffer that will minimize attachment to the solid phase. An enzyme-labeled antibody is then added for detection.
subclass of: enzyme-linked immunosorbent assay (ELISA)
type: Class

Absorbance Reader
type: Class
was approved by: PER-Jim-McCusker
definition: Absorbance readers are used for assays such as ELISA assays, protein and nucleic acid quantification or enzyme activity assays. A light source illuminates the sample using a specific wavelength (selected by an optical filter, or a monochromator), and a light detector located on the other side of the well measures how much of the initial (100%) light is transmitted through the sample: the amount of transmitted light will typically be related to the concentration of the molecule of interest.
subclass of: Microplate Reader

Pentachlorophenol
subclass of: Environmental Phenol
type: Class
definition: An insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor and has been used as such as an experimental tool.
notation: PCP

Femur
type: Class
subclass of: SIO_010046

Several times a week exposure to second hand smoke from E-cigarettes
subclass of: environmental e-cigarette smoke exposure
type: QualityValue
notation: 256
type: Class

Eats Canned Fish
type: Class
definition: The attribute of eating canned fish.
type: QualityValue
subclass of: Dietary Intake
notation: 228
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: FOODON_03302764

Childhood Followup
subclass of: Study Followup
subclass of: SIO_000417
type: Class
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: A point in a study that occurs after the initial baseline of the study and occurs during the study subject's childhood period.

monoethyl phthalate (DEP)
notation: MEP
subclass of: Phthalate
type: Class

Lymphotoxin-alpha
type: Class
subclass of: Protein
notation: TNFB

Demographic
was approved by: PER-Jeanette-Stingone
editorial note: SDD-2016-1431-P01_SG_Dictionary_SDD_v1.xlsx
definition: Demographics are quantifiable characteristics of a given population.
type: Class
subclass of: StudyIndicator

Preschool Child Behavior Checklist Externalizing Subscale
subclass of: Neurocognitive Assessment
type: Class
definition: Subscale of preschool CBCL that assesses externalizing behaviors

Metalloproteinase inhibitor 1
subclass of: Protein
type: Class
notation: TIMP1

lumen
type: SIO_000074
notation: lm

Physical Activity
subclass of: Physical Activity and Fitness
type: QuantityVariable
type: Class

Silver
subclass of: Metal
definition: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
type: Class
notation: Ag

2, 4-Dichlorophenol
definition: 2, 4-dichlorophenol is a colorless crystalline solid with a medicinal odor. Melting point 45°C. Sinks in water. Strong irritant to tissues; toxic by ingestion.
subclass of: Environmental Phenol
type: Class
notation: DCP24

Phenylglyoxylic acid
notation: PGA
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class

Nervous System
type: Class
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior
subclass of: SIO_010003

arachidonic acid
definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
subclass of: Fatty Acid
type: Class
notation: C204N6

Replicate Number
type: Class
subclass of: SampleIndicator
definition: Replicate Number

Composite Score
definition: A single value that is calculated from multiple scores. This composite score can then be used as a single variable in further analysis and comparison. [def-source: NCI]
subclass of: STATO_0000569
type: Class
subclass of: Physical And Mental Assessment
type: QualityVariable

Cesium
type: Class
notation: Cs
definition: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.
subclass of: Metal

blood monocyte count
type: Class
subclass of: SIO_000794

Hemolyzed (covers all three levels) and contaminated
type: Class
subclass of: SIO_001167

Flunisolide HFA (Aerospan)
type: Class
subclass of: Asthma Controller Medication

Interleukin-33
subclass of: Protein
notation: IL33
notation: MMP2
label: 72 kDa type IV collagenase
type: Class

gamma-linolenic acid
notation: C183N6
subclass of: Fatty Acid
type: Class
definition: A C18, ω-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.

Birth Order
type: QualityVariable
type: Class
subclass of: Birth Outcome

microgram per cubic meter
notation: µg/m3
type: SIO_000074

mono-(2-ethylhexyl) terephthalate
notation: MEHTP

asthma
subclass of: DOID 1176
type: Class
type: QualityValue
notation: 193

Microwave Oven Count
editorial note: Putting a note here, but it applies to all of the appliances. These are used to calculate the SES Index that was reported within one of the pilots. So, there needs to be some connection between these terms.
definition: Number of machines in the home used to heat up food using microwaves.
type: Class
subclass of: Household Appliance Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable

cis-vaccenic acid
subclass of: Fatty Acid
definition: The cis isomer of vaccenic acid.
type: Class
notation: C181N7

Pre-Pregnancy
type: Class
was approved by: PER-Jeanette-Stingone
definition: The time before a pregnancy.
subclass of: From Conception
subclass of: SIO_000417
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo

kilogram per mole
notation: kg/mol
type: SIO_000074

Elective Caesarian Section
notation: 19
type: Class
type: QualityValue
definition: A caesarian section that was chosen by the mother but was not medically necessary.
subclass of: Caesarian Section

Cadmium
type: Class
definition: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
subclass of: Metal
notation: Cd

Takes asthma control medications every day
subclass of: Restriction
  some values from: Takes every day
  on property: SIO_000217
subclass of: Asthma Controller Use
type: QualityValue
subclass of: Has taken asthma control medications
type: Class
notation: 278

Technical School
notation: 96
type: Class
subclass of: Education
was approved by: PER-Jeanette-Stingone
definition: Attended a Technical School.
type: QualityValue

colony forming unit
type: SIO_000074
notation: cfu

sievert
type: SIO_000074
notation: Sv

Monocyclohexyl phthalate
type: Class
notation: MCHP
subclass of: Phthalate

gram per milliliter
type: SIO_000074
notation: g/ml

Tungsten
subclass of: Metal
notation: W
definition: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. TUNGSTEN is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.
type: Class

Fall
notation: 213
type: QualityValue
type: Class
subclass of: Season

micron pixel
notation: µm pixel
type: SIO_000074

microliter
notation: µl
type: SIO_000074

volt-hour
notation: Vh
type: SIO_000074

Hospital Readmissions
definition: An episode when a patient who had been discharged from a hospital is admitted again within a specified time interval.
type: Class
subclass of: Hospital Utilization
subclass of: SIO_000794

Heptyl paraben
subclass of: Paraben
type: Class
notation: HePB

Education Grade
subclass of: Education
type: QualityVariable
definition: The highest grade of education achieved
type: Class
was approved by: PER-Jeanette-Stingone

Income 35,000 to 44,999
notation: 266
subclass of: Income 30000 to 49999
type: QualityValue
subclass of: Household Income
type: Class

Grandfather
subclass of: Ancestor
type: Class
definition: The father of your father or mother.

kilodalton
notation: kDa
type: SIO_000074

femtogram
notation: fg
type: SIO_000074

3-Chlorophenol
definition: PHYSICAL DESCRIPTION: White crystals with an odor of phenol. Sinks in and slowly dissolves in water. (NTP, 1992)
notation: MCP3
type: Class
subclass of: Environmental Phenol

Graduated From High School
type: QualityValue
was approved by: PER-Jeanette-Stingone
definition: The quality of having graduated from High School
type: Class
subclass of: High School or Less
notation: 32

2-hydroxybenzo[c]-phenanthrene
subclass of: PAH
notation: BCP2
type: Class

Tibia
type: Class
definition: The major preaxial endochondral bone in the posterior zeugopod.
subclass of: SIO_010046

Metalloproteinase inhibitor 2
subclass of: Protein
notation: TIMP2
type: Class

Fluticasone/salmeterol DPI (Advair Diskus)
type: Class
subclass of: Asthma Controller Medication

Income 15001 to 30000
notation: 161
subclass of: Household Income
type: QualityValue
type: Class
definition: Personal or family annual income bwtween $15,001 and $30,000

mono-isobutyl phthalate (DiBP)
notation: MiBP
subclass of: Phthalate
type: Class

Descendant
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Ancestor
    intersection of: SIO_000485
  on property: inRelationTo
type: Class
subclass of: Relative
definition: The child of a human, or any grandchild, great-grandchild, and so on.
was approved by: PER-Jeanette-Stingone

Fatty Acid
subclass of: Targeted Analyte
type: Class
definition: Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.

Income 75,000 to 84,999
subclass of: Income more than 70001
type: Class
subclass of: Household Income
notation: 262
type: QualityValue
subclass of: Income 50000 to 99999

Physical And Mental Assessment
type: Class
was approved by: PER-Jeanette-Stingone
definition: Physical and Mental Assessments Indicator Class
subclass of: StudyIndicator

pascal second
notation: Pas
type: SIO_000074

cubic meter
notation: m3
type: SIO_000074

Sputum
subclass of: Bodily Fluid
type: Class
definition: Matter ejected from the lungs, bronchi, and trachea, through the mouth. [database_cross_reference: Dorlands_Medical_Dictionary:MerckSource]

Education Grade 6
notation: 118
subclass of: Some Middle School
type: Class
definition: Finished grade 6
type: QualityValue

Sample integrity/quality compromised preventing analysis
subclass of: SIO_001167
type: Class

meter per second
type: SIO_000074
notation: m/s

volt per meter
notation: V/m
type: SIO_000074

PAH
subclass of: Volatile Organic Compound
type: Class

Solid-Phase Sandwich ELISA
was approved by: PER-Jim-McCusker
type: Class
subclass of: Sandwich ELISA

Race or Ethnicity Combined
type: QualityVariable
equivalent class:
  union of: Ethnicity
  union of: Race
definition: Race or ethinicity as a combined concept.
subclass of: Demographic
type: Class

Upper Respiratory Tract Infection
type: QualityVariable
type: Class
subclass of: Health Outcome

mono (3-carboxypropyl) phthalate (multiple)
type: Class
subclass of: Phthalate
notation: MCPP

Monoisopropyl phthalate
subclass of: Phthalate
type: Class
notation: MiPP

Income 45,000 to 54,999
subclass of: Income 40001 to 70000
type: Class
type: QualityValue
notation: 265
subclass of: Household Income

Spring
notation: 211
subclass of: Season
type: QualityValue
type: Class

White Hispanic
definition: White and Hispanic
subclass of: ExO_0000158
type: Class
notation: 145
type: QualityValue
subclass of: Hispanic or Latino Ethnicity

HHEAR
type: Ontology
imports: cogat
imports: uo.owl
imports: cl-basic.owl
imports: sio.owl
imports: prov
version IRI: http://purl.org/twc/HHEAR/1.4
imports: cmo.owl
comment: The Human Health Exposure Analysis Resource (HHEAR) measures exposures that cover the breadth of the “exposome,” which encompasses all environmental exposures including chemical, physical, and biological stressors, as well as lifestyle and social environments, from conception through adulthood. Read more at: https://hhearprogram.org
imports: stato.owl

Aunt
subclass of: Relative
type: QualityValue
definition: The sister of your father or mother or the wife of your uncle.
type: Class
notation: 191

PCB101
type: Class
subclass of: Polychlorobiphenyl
notation: PCB101

Experimental Group
type: QualityValue
subclass of: Population Group
type: Class
notation: 201
definition: A study population that receives the intervention that is the focus of the study.

Mercapturic acids of acrolein and crotonaldehyde
type: Class
subclass of: PAH
notation: AMA

Inductively Coupled Plasma Mass Spectrometer
type: Class
was approved by: PER-Jim-McCusker
definition: A type of mass spectrometry which is capable of detecting metals and several non-metals at concentrations as low as one part in 10^15 (part per quadrillion, ppq) on non-interfered low-background isotopes. This is achieved by ionizing the sample with inductively coupled plasma and then using a mass spectrometer to separate and quantify those ions.
subclass of: Mass Spectrometer

Beginning
definition: A time relative to the beginning of an event
subclass of: Restriction
  has value: 1
  on property: hasValue
subclass of: Relative Time
type: Class

nanomole
notation: nmol
type: SIO_000074

Nulliparous
type: QualityValue
subclass of: Parity
type: Class
notation: 62

Diet Quantity
editorial note: What differentiated diet from nutrition? That is why is this needed since we have the DietAndNutrition Class
type: QuantityVariable
definition: A quantity relating to diet and nutrition.
type: Class
subclass of: SIO_000052
was approved by: PER-Jeanette-Stingone
subclass of: Diet and Nutrition

Cerebrospinal fluid
subclass of: SIO_010046
type: Class
definition: A clear, colorless fluid that is found in the brain and spinal cord.

active eosinophilic esophagitis
equivalent class: Restriction
  on property: isPhenotypeOf
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      on property: hasAttribute
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of more than 25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
type: Class
subclass of: eosinophilic esophagitis

Income more than 100000
type: QualityValue
type: Class
subclass of: Household Income
subclass of: Income more than 70001
subclass of: Income over 95,000
notation: 223

Styrene
type: Class
notation: STY
definition: STYRENE is a colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.
subclass of: Volatile Organic Compound

Result repeated with diluted sample
type: Class
subclass of: SIO_001167

thawed and hemolyzed (covers all three levels)
subclass of: SIO_001167
type: Class

Diet Treatment Medical Therapy
was approved by: PER-Jeanette-Stingone
definition: Diet Treatment is a form of Medical Therapy.
notation: 26
type: Class
subclass of: Medical Therapy Procedure
type: QualityValue

Steroid Treatment form of Medical Therapy
definition: Had a form of treatment which uses steroids.
type: QualityValue
notation: 28
type: Class
was approved by: PER-Jeanette-Stingone
subclass of: Medical Therapy Procedure

Consumed Alcohol
notation: 52
type: QualityValue
subclass of: Alcohol Use
type: Class

Car
notation: 248
type: Class
subclass of: Human Dwelling
type: QualityValue

einstein per square meter per second
type: SIO_000074
notation: einstein/sm2

Income More Than 120000
subclass of: Household Income
definition: Personal or family annual income greater than $120,000
type: QualityValue
subclass of: Income more than 70001
notation: 166
type: Class
subclass of: Income more than 100000

Object
type: Class
subclass of: ScienceIndicator

Perfluorooctanesulfonic acid
definition: Perfluoroalkyls are stable, synthetic chemicals. Perfluoroalkyls are unique because they repel oil, grease, and water. The two perfluoroalkyls made in the largest amounts in the U. S. areperflurooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). Perfluoroalkyls have been used in surface protection products such as carpet and clothing treatments and coating for paper and cardboard packaging. They have also been used in fire-fighting foams.
subclass of: PFC
notation: PFOS
type: Class

Biomolecule
subclass of: Biospecimen
definition: A biospecimen that is composed of molecular entities.
type: Class

Medication
notation: 142
type: Class
definition: A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.
subclass of: Prescription Medication and Dietary Supplements
type: QualityVariable

Matrilysin
subclass of: Protein
type: Class
notation: MMP7

parts per hundred
type: SIO_000074
notation: pph

pascal
type: SIO_000074
notation: Pa

Direct Mercury Analyzer
definition: Direct mercury analysis incorporates the following sequence: thermal decomposition, catalytic conversion, amalgamation, and atomic absorption spectrophotometry. Controlled heating stages are implemented to first dry and then thermally decompose a sample introduced into a quartz tube. A continuous flow of oxygen carries the decomposition products through a hot catalyst bed where halogens, nitrogen, and sulfur oxides are trapped. All mercury species are reduced to Hg(0) and are then carried along with reaction gases to a gold amalgamator where the mercury is selectively trapped. All nonmercury vapors and decomposition products are flushed from the system by the continuous flow of gas. The amalgamator is subsequently heated and releases all trapped mercury to the single-beam, fixed-wavelength atomic absorption spectrophotometer. Absorbance is measured at 253.7 nm as a function of mercury content
was approved by: PER-Jim-McCusker
type: Class
subclass of: PhysicalInstrument

Valid measurement, results repeated and confirmed (0, 33)
subclass of: SIO_001167
type: Class

Medical Therapy Procedure
was approved by: PER-Jeanette-Stingone
subclass of: Medical History
subclass of: SIO_001024
type: Class
definition: Medical Therapy Procedure to aide in treatment.
type: QualityVariable

area density unit
notation: adu
type: SIO_000074

Mitest not capped
subclass of: SIO_001167
type: Class

TNF-alpha
type: Class
notation: TNFA
subclass of: Protein
definition: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
label: Tumor necrosis factor

milliampere
type: SIO_000074
notation: mA

gram per liter
notation: g/L
type: SIO_000074

Perfluorononanoic acid
subclass of: PFC
type: Class
notation: PFNA

(7Z, 10Z, 13Z, 16Z, 19Z)-docosapentaenoic acid
subclass of: Fatty Acid
notation: C225N3
definition: The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.
type: Class

disintegrations per minute
notation: dpm
type: SIO_000074

Date of Birth
was approved by: PER-Jeanette-Stingone
subclass of: Demographic
type: QuantityVariable
type: Class
subclass of: SIO_000417
definition: Date of day on which a person was born.

Ultra Performance Liquid Chromatography - Mass Spectrometer
subclass of: Ultra High Performance Liquid Chromatography Instrument
subclass of: Mass Spectrometer
type: Class
was approved by: PER-Jim-McCusker

Torn, perforated screen
subclass of: SIO_001167
type: Class

Omalizumab (Xolair)
subclass of: Asthma Controller Medication
type: Class

2, 4, 6-Trichlorophenol
subclass of: Environmental Phenol
type: Class
notation: TCP246
definition: 2 4 6-Trichlorophenol is a synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2, 4, 6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2, 4, 6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05)

Behavioral Experimental Paradigm Condition
subclass of: Neurocognitive Assessment
type: Class

Spanish Language
type: Class
notation: 244
subclass of: Acculturation
type: QualityValue
definition: The Spanish Language

SIO_010058
type: QualityValue
notation: 131

Hydroxycotinine
subclass of: Tobacco Metabolite
notation: HCOTT
notation: HCOT
type: Class
label: Hydroxycotinine (total)

Collision-Induced Dissociation (CID)
type: Class
subclass of: TandemMassSpectrometry

Population Group
definition: A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender)
type: QualityVariable
subclass of: StudyIndicator
type: Class

Planned Caesarian Section
type: Class
notation: 18
subclass of: Caesarian Section
type: QualityValue
definition: Planned caesarian section.
was approved by: PER-Jeanette-Stingone

FEF 25-75 Best Value
type: QualityVariable
type: Class
definition: The best FEF 25-75 value achieved by a subject during a series of FEF 25-75 measurements.
subclass of: Forced Expiratory Flow at 25-75 Percent

millimole per liter
type: SIO_000074
notation: mmol/L

2, 2', 3, 4, 4'-Pentabromodiphenyl ether
subclass of: Polybrominated Diphenyl Ether
notation: BDE85
editorial note: To Do: align with CHEBI.
type: Class

Eats Fish Sticks
subclass of: Dietary Intake
definition: The attribute of eating fish sticks.
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: FOODON_03311701
notation: 225
type: QualityValue
type: Class

N-Acetyl-S- (3-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMA
editorial note: To Do: align with CHEBI.

N-A-S-(3-hydrxprpl-1-metl)-L-cys(ng/mL)
type: Class
notation: VOCPMM
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.

Butyl paraben
notation: BuPB
subclass of: Paraben
definition: Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of butylparaben is Allergens.
type: Class

Uncle
definition: The brother of your father or mother or the husband of your aunt.
notation: 192
subclass of: Relative
type: Class
type: QualityValue

South Central Clinic
notation: 273
subclass of: Population Group
type: Class
type: QualityValue

Income 14999 or Less
subclass of: Household Income
notation: 219
type: Class
type: QualityValue

terabyte
type: SIO_000074
notation: TB

Gold
subclass of: Metal
notation: Au
type: Class
definition: GOLD is a yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

picomolar
type: SIO_000074
notation: pM

Some High School
notation: 87
definition: Education Level of Some High School
type: QualityValue
type: Class
was approved by: PER-Jeanette-Stingone
subclass of: High School or Less

Asthma Induced Night Sleeplessness
type: QuantityVariable
subclass of: Restriction
  on property: SIO_001157
  some values from: wheezing or tightness in the chest or cough
subclass of: Physical And Mental Assessment
subclass of: GO_0048266
subclass of: HP_0002360
type: Class

N-Acetyl-S-(trichlorovinyl)-L-cysteine
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: TCVMA

Interlocutory Marital Status
subclass of: Marital Status
notation: 44
type: QualityValue
definition: The condition existing when an order or judgement is considered temporary until either a specified period of time has passed or specific information is provided to assist in rendering a permanent decision.
type: Class

Stress
type: QualityValue
subclass of: Stress Frequency
type: Class
notation: 92
definition: Whether or not a person gets stressed.
was approved by: PER-Jeanette-Stingone

3-hydroxybenzo[c]-phenanthrene
notation: BCP3
subclass of: PAH
type: Class

Born First
subclass of: Birth Order
definition: The first born child
subclass of: NCIT C25509
type: Class
type: QualityValue
notation: 236

Environmental Exposure
editorial note: may need to refine this name in order to clearly differentiate from environmental exposures measured within CHEAR. Perhaps ExternalEnvironmental Exposure. Ok for now but we may want to discuss.
definition: EnvironmentalExposure Indicator Class
type: Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone

Triclocarban
notation: TCC
subclass of: Environmental Phenol
type: Class
definition: Triclocarban is a triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition.

Higher Education
type: Class
type: QualityValue
definition: College or university education beyond the successful completion of high school or grammar school, or the attainment of an approved equivalent
was approved by: PER-Jeanette-Stingone
subclass of: Education
notation: 31

Placenta
type: Class
definition: Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. [database_cross_reference: http://en.wikipedia.org/wiki/Placenta][database_cross_reference: http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm]
subclass of: Tissue
subclass of: Pregnancy Sample

milliliter
notation: ml
type: SIO_000074

gram per cubic centimeter
notation: g/cm3
type: SIO_000074

milliunits per milliliter
type: SIO_000074
notation: mU/ml

mono (2-ethyl-5-oxohexyl) phthalate
notation: MEOHP
subclass of: Phthalate
type: Class

Metabolite
type: Class
subclass of: Small Molecule
definition: The intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Pacific Islander or Native Hawaiian, non-Hispanic
notation: 242
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: Native Hawaiian or Other Pacific Islander
type: Class

Fluticasone/salmeterol HFA(Advair HFA)
type: Class
subclass of: Asthma Controller Medication

Atomic Emission Spectroscopy
subclass of: Atomic Spectroscopy
type: Class

red blood cell count
type: Class
subclass of: SIO_000794

mono-isopropyl phthalate
editorial note: Duplicate of MiPP?
type: Class
subclass of: Phthalate
notation: mIPrP

Antimony
subclass of: Metal
notation: Sb
definition: ANTIMONY is a metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
type: Class

Collection Date of Sample
type: QuantityVariable
definition: Collection Date of Sample
subclass of: SIO_000417
type: Class
was approved by: PER-Jeanette-Stingone

nanogram per milliliter
type: SIO_000074
notation: ng/ml

deciliter
notation: dl
type: SIO_000074

Gas Chromatography
subclass of: Chromatography
type: Class

Magnesium
subclass of: Metal
definition: An element with atomic symbol Mg, atomic number 12, and atomic weight 24.3. Magnesium is an alkaline earth metal and is important to bone structure in human physiology.
notation: Mg
type: Class

Oxybenzone
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
type: Class
notation: OXB
subclass of: Volatile Organic Compound

meter per second per second
notation: m/s2
type: SIO_000074

Initial concentration higher than the highest standard
subclass of: SIO_001167
type: Class

electric field strength unit
notation: Efs
type: SIO_000074

Samples Arrived Thawed and Analyzed
subclass of: SIO_001167
type: Class

SIO_010059
notation: 132
type: QualityValue

Kaufman ABC
type: Class
definition: culturally fair, cognitive ability test for children
subclass of: Neurocognitive Assessment

cells per milliliter
notation: cells per ml
type: SIO_000074

Third Trimester
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
type: Class
subclass of: SIO_000417
subclass of: From Conception
definition: From 29 weeks through 40 weeks.
was approved by: PER-Jeanette-Stingone

nanograms per liter
type: SIO_000074
notation: ng/L

C-C motif chemokine 20
notation: MIP3A
subclass of: Protein
type: Class

Toaster Count
subclass of: Household Appliance Count
definition: Number of appliances used to toast bread.
was approved by: PER-Jeanette-Stingone
type: Class
type: QuantityVariable

Gas Chromatographer-Tandem Mass Spectrometer
definition: MS/MS is the combination of two mass analyzers in one mass spec instrument.
type: Class
subclass of: Gas Chromatographer–Mass Spectrometer
was approved by: PER-Jim-McCusker
subclass of: Tandem Mass Spectrometer

Vanadium
definition: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.
subclass of: Metal
notation: V
type: Class

Phthalate
type: Class
subclass of: Targeted Analyte

ADOS calibrated severity score
type: QuantityVariable
definition: Calibrated severity score on the Total Standardized Autism Diagnostic Observation Schedule (ADOS).
type: Class
subclass of: CAO_01168

becquerel
type: SIO_000074
notation: Bq

quantity of sample insufficient for analysis
subclass of: SIO_001167
type: Class

LAC + USC Med Center
subclass of: Population Group
notation: 269
type: Class
type: QualityValue

blood lymphocyte count
type: Class
subclass of: SIO_000794

Head
subclass of: SIO_010046
type: Class

Cold Vapor Atomic Fluorescence Spectroscopy Instrument
type: Class
subclass of: Atomic Fluorescence Spectroscopy Instrument
definition: Used in the measurement of trace amounts of volatile heavy metals such as mercury, cold vapour AFS makes use of the unique characteristic of mercury that allows vapour measurement at room temperature.
was approved by: PER-Jim-McCusker

Cobalt
definition: COBALT is a trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
type: Class
notation: Co
subclass of: Metal

valid measurement
subclass of: SIO_001167
type: Class

Healthcare Access
type: Class
subclass of: StudyIndicator
definition: Healthcare Access

A Sample has a Pairing
subclass of: SIO_001049
definition: Refers to having paired samples.
was approved by: PER-Jeanette-Stingone
editorial note: This actually should be a process. What should we do?
type: Class

Hemolyzed (covers all three levels) and lipemic
subclass of: SIO_001167
type: Class

Malarial Retinopathy
type: QualityValue
subclass of: Retinopathy
type: Class
notation: 130
definition: Retinopathy due to malaria.

Irregular result, no concentration reported
type: Class
subclass of: SIO_001167

Fenton Preterm Growth Chart
type: Class
definition: A growth chart adusted for gestational age
subclass of: SIO_000442

1-hydroxychrysene
subclass of: PAH
type: Class
notation: CHRY1

Fenton Weighted Z-Score
type: QuantityVariable
subclass of: Z-Score
type: Class
subclass of: SIO_001245
definition: Derived from Birth Weight, Gestational Age, and Child Sex
was approved by: PER-Jeanette-Stingone
subclass of: Birth Outcome
subclass of: Class
  intersection of: SIO_001245
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: HHEAR_00504
  intersection of: Restriction
    on property: wasDerivedFrom
    some values from: Fenton Preterm Growth Chart
  intersection of: Restriction
    some values from: Gestational Age at Birth
    on property: wasDerivedFrom

Haptoglobin
notation: HAPTOGLOBIN
type: Class
subclass of: Protein

Screening
subclass of: SIO_000417
type: Class
was approved by: PER-Jeanette-Stingone
definition: The time period during which a screening process is used to determine the inclusion of a subject in a study.

mono (2-ethyl-5-hydroxyhexyl) phthalate
type: Class
notation: MEHHP
subclass of: Phthalate

Blood Component
subclass of: Bodily Fluid
type: Class
definition: A derivable component of whole blood.

Alcohol Use
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 83
type: QualityValue
type: Class
definition: Uses Alcohol

Failed negative control
type: Class
subclass of: SIO_001167

Interleukin-4
subclass of: Protein
type: Class
notation: IL4

FEF 25-75 Predicted Value
type: Class
subclass of: Forced Expiratory Flow at 25-75 Percent
type: QualityVariable
definition: The expected or predicted FEF 25-75 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Electron Transfer Dissociation (ETD)
subclass of: TandemMassSpectrometry
type: Class

neuron
subclass of: Cell
type: Class

picogram
notation: pg
type: SIO_000074

Multiracial
editorial note: Not part of current prov for Race. Should we remove this concept?
subclass of: Race
type: Class
notation: 54
type: QualityValue
subclass of: Non-White
definition: Having ancestors of several or various races.
was approved by: PER-Jeanette-Stingone

watt per meter kelvin
type: SIO_000074
notation: W/mK

Eats Fresh Fish
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: FOODON_03315446
subclass of: Dietary Intake
type: Class
notation: 227
type: QualityValue
definition: The attribute of eating fresh fish.

mono-hexyl phthalate
type: Class
notation: mHxP
subclass of: Phthalate

Eisner Health
type: QualityValue
notation: 270
type: Class
subclass of: Population Group

Abnormal hemoglobin variant observed
subclass of: SIO_001167
type: Class

Study Baseline
subclass of: SIO_000417
type: Class
definition: Point in study set to initial point.

Biological Response
type: Class
definition: Indicator of biological response to environmental exposure
subclass of: StudyIndicator
editorial note: abolic_SDD_v1.xlsx

Adult
subclass of: Developmental Quality
notation: 3
type: QualityValue
subclass of: Demographic
was approved by: PER-Jeanette-Stingone
definition: Refers to a person above a threshold age.
type: Class

Not Current Student
subclass of: SIO_001326
notation: 141
type: Class
definition: The state of an individual not currently engaged in educational activity as a pupil.
type: QualityValue

Soil Floor
type: QualityValue
was approved by: PER-Jeanette-Stingone
type: Class
definition: The flooring is made of soil.
notation: 84
subclass of: Floor Type

Never Married
definition: Indicates a person who has never been married or whose marriages have been annulled.
type: Class
type: QualityValue
subclass of: Unmarried
notation: 38

Quantity of sample insufficient for repeat analysis
type: Class
subclass of: SIO_001167

Methylation Assay
subclass of: SIO_001007
type: Class
definition: An assay that measures the methylation levels of sections of a genome.

mass volume percentage
notation: (w/v)
type: SIO_000074

megavolt
notation: MV
type: SIO_000074

Monocyte
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
subclass of: Lymphocyte
type: Class

SIO_000554
notation: 134
type: QualityValue

RNA Sequencing
subclass of: Nucleic Acid Sequencing
type: Class

Organochlorine Compound
subclass of: Targeted Analyte
type: Class

parts per billion
type: SIO_000074
notation: ppb

Reactive Airway Disease
definition: Coughing, wheezing, or shortness of breath that is triggered by allergens, infection, or other irritants. [def-source: NCI]
type: Class
subclass of: NCIT C27557
type: QualityValue
notation: 186

Visit
definition: The time interval of an encounter between a study subject and a study administrator.
subclass of: SIO_000417
type: Class

tesla
type: SIO_000074
notation: Tesla

Sample frozen
subclass of: SIO_001167
type: Class

2, 2', 4, 4'-Tetrabromodiphenyl ether
editorial note: To Do: align with CHEBI.
subclass of: Polybrominated Diphenyl Ether
type: Class
notation: BDE47

Part Time Employment
subclass of: Occupation
type: Class
notation: 65
type: QualityValue
definition: Employment involving less than the standard or customary working time.

Nickel
subclass of: Metal
notation: Ni
type: Class
definition: NICKEL is a trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.

Polymerase Chain Reaction
type: Class
subclass of: SIO_001007

mono(7-carboxyheptyl)phthalate
type: Class
subclass of: Phthalate
notation: mCHpP

Tin
subclass of: Metal
definition: TIN is a trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.
notation: Sn
type: Class

Non-White
definition: A race other than white.
subclass of: Race
type: Class
type: QualityValue
notation: 149

Mercapturic acids of 1, 3-butadiene
type: Class
subclass of: Tobacco Metabolite
notation: HEMA

Iodine
definition: Iodine is a nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
notation: I
subclass of: Element
type: Class

Tissue
type: Class
subclass of: Biospecimen

N-Ace-S-(2-carbamoylethyl)-L-cys(ng/mL)
subclass of: Volatile Organic Compound
type: Class
notation: VOCAAM
editorial note: To Do: align with CHEBI.

Bisphenol F
notation: BPF
type: Class
subclass of: Environmental Phenol

Color Object Association Test
type: Class
definition: a reliable and a valid measure of declarative memory for healthy children ages 18-36 months, living in a disadvantaged community
subclass of: Neurocognitive Assessment

8-hydroxy-2'-deoxyguanosine
subclass of: Biomolecule
type: Class
subclass of: Biological Response
definition: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

monooxoisononyl phthalate (DiNP)
notation: MONP

Allergy
type: Class
type: QualityValue
notation: 279
subclass of: SIO_010056

curie per liter
notation: curie/l
type: SIO_000074

N-Ace-S-(N-methlcarbamoyl)-L-cys(ng/mL)
notation: VOCAMC
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.

Stress Frequency
subclass of: SIO_000475
editorial note: Again, we might want to link this to a specific assessment?
type: Class
subclass of: Mental Health
was approved by: PER-Jeanette-Stingone
type: QualityVariable
definition: How frequently a person gets stressed.

Income 85,000 to 94,999
subclass of: Household Income
notation: 261
type: Class
subclass of: Income 50000 to 99999
subclass of: Income more than 70001
type: QualityValue

Niobium
type: Class
notation: Nb
definition: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)
subclass of: Metal

Mometasone DPI (Asmanex)
subclass of: Asthma Controller Medication
type: Class

volume percentage
notation: %(v/v)
type: SIO_000074

candela
notation: cd
type: SIO_000074

hertz
type: SIO_000074
notation: Hz

curie
type: SIO_000074
notation: Ci

o-Xylene
definition: O-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)
subclass of: Volatile Organic Compound
type: Class
notation: OXY

Antimalarial
subclass of: Medication
type: QualityValue
definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
type: Class
notation: 120

hexadecanoic acid
type: Class
subclass of: Fatty Acid
notation: C160
definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Mono-n-pentyl phthalate
editorial note: Duplicate of mPeP?
type: Class
notation: MPP
subclass of: Phthalate

Fever
notation: 123
subclass of: Phenotype
definition: Elevated body temperature due to failed thermoregulation.
type: Class
type: QualityValue

Spirometry Outcomes Did Not Meet Guidelines
subclass of: Spirometry Outcome
subclass of: Restriction
  some values from: SIO_001310
  on property: SIO_000217
type: QualityValue
notation: 281
type: Class

Age
type: Class
type: QuantityVariable
subclass of: Demographic

Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
definition: A tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation.
subclass of: Inductively Coupled Plasma Mass Spectrometer
was approved by: PER-Jim-McCusker
type: Class

Intensive Care Unit
notation: 168
type: Class
subclass of: Destination
type: QualityValue
definition: A health care facility unit that provides intensive care to critically ill patients and patients with complex medical problems who require constant monitoring or special therapy.

Predominantly fibrous material
subclass of: SIO_001167
type: Class

Arsenocholine
subclass of: Arsenic Species
type: Class
notation: Arsenocholine

Preschool Child Behavior Checklist Internalizing Subscale
subclass of: Neurocognitive Assessment
type: Class
definition: Subscale of preschool CBCL that assesses internalizing behaviors

Asthma Severity Index Composite Score (CASI)
subclass of: NCIT C119810
subclass of: Physical And Mental Assessment
type: QualityVariable
type: Class
definition: The Composite Asthma Severity Index (CASI) is a comprehensive severity scale combining multiple facets of asthma severity: impairment, risk, and treatment The CASI score, which was developed as a research tool for intervention studies, ranges from 0 to 20 points, with higher scores indicating higher levels of severity, and includes 5 domains: day symptoms and albuterol use, night symptoms and albuterol use, controller treatment, lung function measures, and exacerbations. (Source: Minimally Important Differences and Risk Levels for the Composite Asthma Severity Index Rebecca Z. Krouse, et al.)
subclass of: Composite Score
subclass of: Health Outcome

FVC Predicted Value
type: Class
definition: The expected or predicted FVC value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.
type: QualityVariable
subclass of: CMO_0000251

Nicotine
type: Class
notation: NIC
definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
subclass of: Tobacco Metabolite

Education Grade 4
type: QualityValue
notation: 116
definition: Finished grade 4
subclass of: Elementary School
type: Class

Preterm Birth
subclass of: Birth Outcome
notation: 88
type: QualityValue
was approved by: PER-Jim-McCusker
definition: Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.
type: Class

Refractometer
was approved by: PER-Jim-McCusker
type: Class
subclass of: PhysicalInstrument
definition: A laboratory or field device for the measurement of an index of refraction (refractometry). The index of refraction is calculated from Snell's law while for mixtures, the index of refraction can be calculated from the composition of the material using several mixing rules such as the Gladstone–Dale relation and Lorentz–Lorenz equation.

Replicate
type: Class
subclass of: Analyte
definition: The value contains data for a repeat of the study sample

Education Grade 2
subclass of: Some Elementary School
type: QualityValue
definition: Finished grade 2
type: Class
notation: 114

Short Stay
notation: 170
subclass of: Destination
type: QualityValue
definition: A patient encounter where the patient is admitted to a health care facility for a predetermined length of time, usually less than 24 hours. [def-source:
type: Class

dots per inch
notation: dpi
type: SIO_000074

Religion
definition: Religious Belief
type: QualityVariable
subclass of: Demographic
type: Class

Mometasone HFA (Asmanex HFA)
subclass of: Asthma Controller Medication
type: Class

Interleukin-6
definition: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
subclass of: Protein
type: Class
notation: IL6

Multi Residence Building
notation: 231
type: Class
type: QualityValue
subclass of: Human Dwelling
subclass of: Residential Building
definition: A residential building that contains more than one apartment, town house, condo, or other single family dwelling space.

Leukocyte
subclass of: Blood Component
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
type: Class

Birth Year
type: Class
subclass of: SIO_000428
type: QualityValue
definition: The year in which a person was born.
notation: 198

Nicotine (total)
notation: NICT
subclass of: Tobacco Metabolite
editorial note: To Do: align with CHEBI.
type: Class

Agilent 1100 HPLC
was approved by: PER-Jim-McCusker
subclass of: High-Performance Liquid Chromatography
type: Class

Targeted Sequencing
subclass of: Nucleic Acid Sequencing
type: Class
definition: Nucleic acid sequencing that limits the scope of sequencing by filtering out portions of the nucleic acids that do not meet some criteria.

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine
editorial note: To Do: align with CHEBI.
notation: AMCC
type: Class
subclass of: Volatile Organic Compound

Freeze/Thaw Cycles Count
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000794
type: QuantityVariable
type: Class
definition: Number of Freeze/Thaw cycles.

lux
type: SIO_000074
notation: lx

Income 30001 to 50000
type: Class
notation: 162
definition: Personal or family annual income bwtween $30,001 and $50,000
subclass of: Household Income
type: QualityValue

Perfluoro-n-pentanoic acid
notation: PFPeA
type: Class
subclass of: PFC

nanomolal
type: SIO_000074
notation: nmolal

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine
notation: AAMA
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.

Widowed
type: QualityValue
notation: 39
subclass of: Unmarried
definition: Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.
type: Class

nanomolar
notation: nM
type: SIO_000074

Matrix metalloproteinase-9
notation: MMP9
type: Class
subclass of: Protein

Vitamin D
subclass of: Biomolecule
definition: Vitamin D is a group of fat-soluble prohormones, which can be obtained from sun exposure, food and supplements. Vitamin D is biologically inactive and converted to the biologically active calcitriol via double hydroxylation in the body.
type: Class
subclass of: Diet and Nutrition

liter
type: SIO_000074
notation: L

2-Chlorophenol
subclass of: Environmental Phenol
type: Class
definition: 2-chlorophenol is a colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g / cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).
notation: MCP2

alpha-linolenic acid
definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.
notation: C183N3
type: Class
subclass of: Fatty Acid

Some Elementary School
type: QualityValue
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: High School or Less
definition: Attended Some Elementary School
notation: 86

College Graduate
was approved by: PER-Jeanette-Stingone
definition: The quality of having graduated from College
subclass of: Higher Education
type: Class
notation: 12
type: QualityValue

Family history
type: Class
subclass of: Medical History
type: QualityVariable

Hunan Dwelling
subclass of: Human Dwelling
type: QualityVariable
type: Class

Foster
subclass of: Non-Biological Relative
definition: Fosterage, the practice of a family bringing up a child not their own, differs from adoption in that the child's parents, not the foster-parents, remain the acknowledged parents. In many modern western societies foster care can be organized by the state to care for children with troubled family backgrounds, usually on a temporary basis. In many pre-modern societies fosterage was a form of patronage, whereby influential families cemented political relationships by bringing up each other's children, similar to arranged marriages, also based on dynastic or alliance calculations.
type: Class

Income 15,000 to 24,999
notation: 268
subclass of: Household Income
type: QualityValue
subclass of: Income 15000 to 29999
type: Class

2, 3, 4, 6-Tetrachlorophenol
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)
notation: TeCP2346
type: Class
subclass of: Environmental Phenol

bronchiolitis
notation: 194
subclass of: DOID 850
type: Class
type: QualityValue

SIO_000784
type: QualityValue
notation: 109

9-hydroxyphenanthrene
type: Class
notation: PHEN9
subclass of: PAH

4, 4'-DDT
type: Class
notation: PPDDT
subclass of: Organochlorine Compound

dimethylphosphate
subclass of: Alkyl Phosphate Pesticide Metabolite
editorial note: To Do: align with CHEBI.
type: Class
notation: DMP

Birth
type: Class
subclass of: From Birth
definition: The ending of a pregnancy by one or more babies leaving a woman's uterus by vagina passage or c-section.
subclass of: SIO_000417
was approved by: PER-Jeanette-Stingone
subclass of: Beginning

Interferon gamma
notation: IFNG
type: Class
subclass of: Protein

Liquid Chromatography - Tandem Mass Spectrometer
type: Class
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker
subclass of: Tandem Mass Spectrometer
subclass of: Liquid Chromatography–Mass Spectrometer

Urine grossly hematuric
subclass of: SIO_001167
type: Class

Difference
subclass of: SIO_000052
definition: Variables derived from taking the difference of two other variables. For example, the first difference of a time series {yt} is defined as Dyt = yt - yt-1
type: Class

2, 2', 4, 4', 5-Pentabromodiphenyl ether
notation: BDE99
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Polybrominated Diphenyl Ether

N-Acetyl-S-(1-phenyl-2-hydroxyethyl-L-cysteine + N-Acetyl-S-(2-phenyl-2-hydroxyethyl)-L-cysteine
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class
notation: PHEMA

2-hydroxyfluorene
subclass of: PAH
type: Class
notation: FLUO2

Analyte
type: Class
subclass of: SIO_010004

N-Acetyl-S- (3, 4-dihydroxybutyl)-L-cysteine
editorial note: To Do: align with CHEBI.
notation: DHBMA
type: Class
subclass of: Volatile Organic Compound

Income over 95,000
subclass of: Household Income
type: Class
type: QualityValue
subclass of: Income more than 70001
notation: 260

Tobacco Smoke Exposure
subclass of: Environmental Exposure
notation: 98
type: Class
type: QualityValue

Education Grade 3
notation: 115
subclass of: Some Elementary School
definition: Finished grade 3
type: Class
type: QualityValue

Serum
type: Class
subclass of: Blood Component
definition: Liquid derived from blood plasma that has clotting factors removed. [database_cross_reference: http://en.wikipedia.org/wiki/Serum_(blood)][database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Gadolinium
subclass of: Metal
type: Class
definition: Gadolinium. An element of the rare earth family of metals. GADOLINIUM has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
notation: Gd

Married
type: QualityValue
definition: Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.
type: Class
notation: 37
subclass of: Marital Status

Plasma
subclass of: Blood Component
type: Class
definition: The liquid component of blood, in which erythrocytes are suspended. [database_cross_reference: http://orcid.org/0000-0002-6601-2165]

3, 4-Dihydroxy benzoic acid
notation: DHB34
type: Class
subclass of: Environmental Phenol

Histidine-rich protein PFHRP-II
subclass of: Protein
type: Class

Forced Expiratory Flow at 25-75 Percent
type: Class
subclass of: CMO_0000094
type: QualityVariable

Interleukin-9
subclass of: Protein
type: Class
notation: IL9

Parity
type: QuantityVariable
subclass of: Pregnancy Characteristic
subclass of: SIO_000794
type: Class
was approved by: PER-Jeanette-Stingone
definition: The number of time that a viviparous organism has given birth

candela per square meter
notation: cd/m2
type: SIO_000074

N-Acetyl-S-(1, 2-dichlorovinyl)-L-cysteine
notation: DCVMA12
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound

dimethylthiophosphate
type: Class
editorial note: To Do: align with CHEBI.
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DMTP

parts per trillion
notation: ppt
type: SIO_000074

beta-hexachlorocyclohexane
subclass of: Organochlorine Compound
notation: BHCH
type: Class

Hospital Utilization
definition: Hospital Utilization
type: Class
was approved by: PER-Jeanette-Stingone
subclass of: Healthcare Access

Biological Sex
subclass of: Demographic
type: Class
type: QualityVariable

Below LOD, results repeated and confirmed (37, 33)
subclass of: SIO_001167
type: Class

Gravimetric Analysis Instrument
was approved by: PER-Jim-McCusker
type: Class
definition: Gravimetric analysis describes a set of methods used in analytical chemistry for the quantitative determination of an analyte (the ion being analyzed) based on its mass. The principle behind this type of analysis is that once an ion's mass has been determined as a unique compound, that known measurement can then be used to determine the same analyte's mass in a mixture, as long as the relative quantities of the other constituents are known.
subclass of: PhysicalInstrument

Dietary Intake
type: QualityVariable
type: Class
subclass of: Diet Quantity
definition: The attribute of eating some food.
subclass of: SIO_001105

Preschool Child Behavior Checklist
definition: Child Behavior Checklist for ages 1 ½ through 5
type: Class
subclass of: Neurocognitive Assessment

Born Second
type: Class
notation: 237
type: QualityValue
subclass of: NCIT C25666
subclass of: Birth Order
definition: The second born child

Difference of Weight-to-Length Z-Scores from 0 to 6 Months
type: QualityVariable
subclass of: Difference of Z-Scores
type: Class
definition: The arithmetic difference between the weight-to-length Z-scores for a child taken at birth and at six months.

Autism Spectrum Disorder
notation: 151
subclass of: Developmental Disorder of Mental Health
type: Class
type: QualityValue

trans, trans -Muconic acid
subclass of: Volatile Organic Compound
type: Class
notation: MU
editorial note: To Do: align with CHEBI.

Tetrachloroethene
definition: TETRACHLOROETHYLENE is a chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.
notation: TCE
subclass of: Volatile Organic Compound
type: Class

PCB180
notation: PCB180
subclass of: Polychlorobiphenyl
type: Class

steradian
notation: sr
type: SIO_000074

No preservative added
type: Class
subclass of: SIO_001167

parasite count
type: Class
subclass of: Concentration

Insulin
subclass of: Metabolite
type: Class
subclass of: Protein
definition: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.

Born Sixth Or Later
definition: The sixth or later born child
subclass of: NCIT C46126
notation: 241
subclass of: Birth Order
type: QualityValue
type: Class

Medical Leave
notation: 246
subclass of: Occupation
type: Class
type: QualityValue

foot candle
notation: ft-c
type: SIO_000074

molal
type: SIO_000074
notation: mol/kg

mono (7-COOH-2-methyloctyl) phthalate
notation: MCOMOP
subclass of: Phthalate
type: Class

Overloaded filter
type: Class
subclass of: SIO_001167

Never Smoked
was approved by: PER-Jeanette-Stingone
subclass of: Smoking Status
definition: The quality of never smoking in the past.
type: Class
type: QualityValue
notation: 56

Ethylbenzene
type: Class
subclass of: Volatile Organic Compound
definition: Ethylbenzene is mainly used in the manufacture of styrene. Acute (short-term) exposure to ethylbenzene in humans results in respiratory effects, such as throat irritation and chest constriction, irritation of the eyes, and neurological effects such as dizziness. Chronic (long-term) exposure to ethylbenzene by inhalation in humans has shown conflicting results regarding its effects on the blood. Animal studies have reported effects on the blood, liver, and kidneys from chronic inhalation exposure to ethylbenzene. Limited information is available on the carcinogenic effects of ethylbenzene in humans. In a study by the National Toxicology Program (NTP), exposure to ethylbenzene by inhalation resulted in an increased incidence of kidney and testicular tumors in rats, and lung and liver tumors in mice. EPA has classified ethylbenzene as a Group D, not classifiable as to human carcinogenicity.
notation: EB

Interfering substances present
type: Class
subclass of: SIO_001167

GO_0016265
deprecated: true

watt per steradian
type: SIO_000074
notation: W/sr

Interleukin-21
type: Class
notation: IL21
subclass of: Protein

cigarettes per day
notation: cigs / day
type: SIO_000074

Polychlorobiphenyl
subclass of: Organochlorine Compound
type: Class

fine respirable suspended particulate matter
type: Class
subclass of: Air Pollutant
type: QualityVariable

Daily Exposure to Second Hand Smoke
subclass of: environmental tobacco smoke exposure
notation: 250
type: QualityValue
type: Class

Body Weight Quality
definition: A categorization of body mass relative to the height, as defined using Body Mass Index.
type: Class
subclass of: SIO_000005
subclass of: Anthropometry

Matched Pair of Subjects
type: Class
subclass of: SIO_000616
definition: A set of 2 subjects which result from a pairing process which assigns subject to a set based on a pairing rule/criteria

Uranium
notation: U
type: Class
subclass of: Metal
definition: Uranium. A radioactive element of the actinide series of metals. URANIUM has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.

Caesarian Section
type: QualityValue
definition: Caesarian Section Medical Procedure. One-third of pregnancies in the US end in C-Sections.
notation: 20
type: Class
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery

Biological Relative
subclass of: Relative
definition: Being from the same biological kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person.
type: Class

DNA
type: Class
subclass of: Macromolecule

Red Blood Cell
type: Class
subclass of: Blood Component
definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.

Result reported based on fewer replicates than required
subclass of: SIO_001167
type: Class

Several times a week exposure to second hand smoke
subclass of: environmental tobacco smoke exposure
type: Class
notation: 251
type: QualityValue

Social Affect + Restricted and Repetitive Behavior Total
type: QuantityVariable
type: Class
subclass of: CAO_01168
definition: Total Standardized Autism Diagnostic Observation Schedule (ADOS) score.

Saliva
type: Class
subclass of: Bodily Fluid
definition: A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions. [database_cross_reference: http://en.wikipedia.org/wiki/Saliva][database_cross_reference: GO:0046541]

environmental tobacco smoke exposure
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 153
type: QualityValue
type: Class

Ancestor
definition: An ancestor or forebear is a parent or (recursively) the parent of an ancestor (i.e., a grandparent, great-grandparent, great-great-grandparent, and so forth). Ancestor is "any person from whom one is descended. In law the person from whom an estate has been inherited."
subclass of: Relative
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      all values from: Descendant
      on property: hasRole
    intersection of: SIO_000485
type: Class
was approved by: PER-Jeanette-Stingone

2-hydroxynaphthalene
subclass of: PAH
notation: NAP2
type: Class

Mercapturic acid of benzene
subclass of: PAH
notation: SPMA
type: Class

Tandem Mass Spectrometer
subclass of: Mass Spectrometer
was approved by: PER-Jim-McCusker
type: Class
definition: Tandem mass spectrometry, also known as MS/MS or MS2, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. In a tandem mass spectrometer, ions are formed in the ion source and separated by mass-to-charge ratio in the first stage of mass spectrometry (MS1). Ions of a particular mass-to-charge ratio (precursor ions) are selected and fragment ions (product ions) are created by collision-induced dissociation, ion-molecule reaction, photodissociation, or other process. The resulting ions are then separated and detected in a second stage of mass spectrometry (MS2).

Second Trimester
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
was approved by: PER-Jeanette-Stingone
subclass of: From Conception
subclass of: SIO_000417
type: Class
definition: From week 13 through 28. Around the middle of the second trimester, movement of the fetus may be felt. At 28 weeks, more than 90% of babies can survive outside of the uterus if provided with high-quality medical care.

Gray
notation: Gy
type: SIO_000074

Polybrominated Diphenyl Ether
type: Class
subclass of: Targeted Analyte

N-Acetyl-S-(trichlorovinyl)-L-cys(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCTCV
subclass of: Volatile Organic Compound
type: Class

Specimen analyzed in singlicate for an assay that requires duplicates
type: Class
subclass of: SIO_001167

docosanoic acid
type: Class
definition: A straight-chain, C22, long-chain saturated fatty acid.
subclass of: Fatty Acid
notation: C220

dehydroepiandrosterone sulfate
subclass of: Metabolite
type: Class
subclass of: Biological Response
definition: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

millicurie
type: SIO_000074
notation: mCi

Fresh Vegetable Consumption
definition: Whether or not Fresh Vegetables are consumed.
notation: 29
subclass of: Fresh Vegetable Consumption Frequency
type: QualityValue
type: Class
was approved by: PER-Jeanette-Stingone

kilobyte
notation: kB
type: SIO_000074

angstrom
notation: Ang
type: SIO_000074

Preschool
notation: 112
definition: Finished preschool
subclass of: Education Grade
type: QualityValue
type: Class

Divorced
type: Class
notation: 40
type: QualityValue
subclass of: Unmarried
definition: Indicates a person whose marriage has been legally dissolved and has not remarried.

Never takes asthma control medications
notation: 274
subclass of: Restriction
  some values from: Never takes
  on property: SIO_000217
type: Class
subclass of: Asthma Controller Use
type: QualityValue

Element
subclass of: Targeted Analyte
type: Class

Pregnancy
type: Class
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
was approved by: PER-Jeanette-Stingone
subclass of: SIO_000417
subclass of: From Conception
definition: The time during which one or more offspring develops inside a woman.
subclass of: Pregnancy Characteristic

base pair
notation: bp
type: SIO_000074

Cell
type: Class
subclass of: Biospecimen

siemens
notation: 1/AV
type: SIO_000074

micrograms per meter cubed
notation: µg/m3
type: SIO_000074

Trans-Nonachlor
type: Class
subclass of: Organochlorine Compound
notation: TNON

Perfluorodecanoic acid
subclass of: PFC
type: Class
notation: PFDA

TermBirth
subclass of: Birth Outcome
notation: 97
type: QualityValue
type: Class

Platelet
subclass of: Blood Component
type: Class
definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

Abdomen
subclass of: SIO_010046
type: Class

Non-smoker
notation: 59
definition: Doesn't smoke cigarettes.
type: Class
subclass of: Smoking Status
type: QualityValue

Mono-n-octyl phthalate
type: Class
notation: MOP
subclass of: Phthalate

Drinking Water
definition: Drinking water is water which may be consumed by humans with no adverse effects on their health.
definition: Drinking Water
type: Class
subclass of: Environmental Material

Asian Non-Hispanic
type: Class
subclass of: Non-Hispanic Ethnicity
type: QualityValue
notation: 217
subclass of: Asian

Light Bulb Count
subclass of: Housing Characteristic
definition: Total Number of Lightbulbs in the Home
type: Class
subclass of: SIO_000794
type: QuantityVariable
was approved by: PER-Jeanette-Stingone

femtomole
notation: fmol
type: SIO_000074

roentgen
notation: Roentgen
type: SIO_000074

Study Followup
definition: A point in a study where data is gathered after the initial baseline.
subclass of: SIO_000417
type: Class

Childhood Cohort Study
type: Class
subclass of: CohortStudy

Inorganic Mercury (Hg2+)
type: Class
subclass of: Mercury Species
notation: Hg2

Interleukin-1 beta
definition: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
subclass of: Protein
type: Class
notation: IL1B

No Hct, Hct=40 assumed
subclass of: SIO_001167
type: Class

disintegrations per second
type: SIO_000074
notation: dps

Turbid
type: Class
subclass of: SIO_001167

Result repeated and confirmed
type: Class
subclass of: SIO_001167

Sustained Physical Activity
type: Class
type: QualityVariable
definition: Physical activity that is at least 30 minutes in duration.
subclass of: Physical Activity

Control Group
type: Class
type: QualityValue
definition: A group used as a standard of comparison in a control experiment.
subclass of: Population Group
notation: 200

Analyzed at a later date than rest of samples on worksheet (not a repeat)
subclass of: SIO_001167
type: Class

Retinopathy
definition: Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.
subclass of: Phenotype
notation: 129
type: Class
type: QualityValue

Fluticasone/vilanterol (Breo Ellipta)
type: Class
subclass of: Asthma Controller Medication

4-hydroxychrysene
notation: CHRY4
subclass of: PAH
type: Class

Benzophenone
type: Class
subclass of: Targeted Analyte

Rarely exposed to second hand smoke
subclass of: environmental tobacco smoke exposure
type: Class
type: QualityValue
notation: 253

Mono-2-ethyl-5-oxohexylterephthalate
notation: MEOHTP

newton per meter
notation: N/m
type: SIO_000074

Income 65,000 to 74,999
type: QualityValue
subclass of: Income 50000 to 99999
notation: 263
type: Class
subclass of: Household Income

Concentration
type: Class
type: QuantityVariable
subclass of: Laboratory Result

radian per second
type: SIO_000074
notation: rad/s

nanosecond
type: SIO_000074
notation: ns

Washing Machine Count
type: Class
subclass of: Household Appliance Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable
definition: Number of machines used for washing clothes in the home.

Vaginal Birth
type: QualityValue
subclass of: Route Of Delivery
definition: Had a birthing occur via the vagina.
editorial note: Again, can we add a delivery class
subclass of: Pregnancy Characteristic
type: Class
subclass of: birthing
notation: 24

colony forming unit per milliliter
notation: cfu/ml
type: SIO_000074

glucose
subclass of: Metabolite
subclass of: Biological Response
definition: An aldohexose used as a source of energy and metabolic intermediate.
type: Class

megabasepair
type: SIO_000074
notation: Mb

abnormal cell
subclass of: Cell
type: Class

Health Maintenance Organization Insurance
type: Class
notation: 49
subclass of: Insurance
type: QualityValue

Icteric
type: Class
subclass of: SIO_001167

cubic meter per kilogram
type: SIO_000074
notation: m3/kg

type 2 diabetes mellitus
type: QualityValue
subclass of: DOID 9351
notation: 181
type: Class

kilogram meter per second
type: SIO_000074
notation: kg.m/s

Panel change
subclass of: SIO_001167
type: Class

microampere
notation: µA
type: SIO_000074

t, t-Muconic acid(ng/mL)
editorial note: To Do: align with CHEBI.
notation: VOCMUC
subclass of: Volatile Organic Compound
type: Class

Canned Food Consumption
was approved by: PER-Jeanette-Stingone
notation: 9
definition: Whether or not canned food is consumed.
type: Class
subclass of: Canned Food Consumption Frequency
type: QualityValue

Mandelic acid
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: MA

molar
type: SIO_000074
notation: M

Liquid Chromotography-Multistage Mass Spectrometery
type: Class
subclass of: MassSpectrometry

Used to take but no longer
subclass of: SIO_001288
type: Class

Smoking Status
type: QualityValue
subclass of: SIO_001326
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: ExO_0000038
notation: 197
type: Class
editorial note: We need to discuss this entire hierarchy.

N-acetyl-S-(2-cyanoethyl)-L-cyst(ng/mL)
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: VOCCYM

nanogram
notation: ng
type: SIO_000074

Benzophenone-1
notation: BP1
subclass of: Benzophenone
type: Class

Perfluorobutanoic acid
subclass of: PFC
type: Class
notation: PFBA

Income 50000 to 99999
type: QualityValue
type: Class
notation: 222
subclass of: Household Income

Esophagus
type: Class
subclass of: SIO_010003

3-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO3

Microarray Assay
subclass of: SIO_001007
type: Class
definition: An assay that uses a microarray to perform measurements.

Public Insurance
notation: 79
type: Class
type: QualityValue
subclass of: Insurance

High Performance Liquid Chromatography - Tandem Mass Spectrometer
subclass of: High-Performance Liquid Chromatography-Mass Spectrometry
subclass of: Liquid Chromatography - Tandem Mass Spectrometer
type: Class
was approved by: PER-Jim-McCusker
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS (Tandem MS) is the combination of two mass analyzers in one mass spec instrument.

diethyldithiophosphate
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DEDP
editorial note: To Do: align with CHEBI.
type: Class

2-4 Residence Building
type: Class
definition: A residential building that contains between two and four apartments, town houses, condos, or other single family dwelling spaces.
type: QualityValue
notation: 232
subclass of: Multi Residence Building

picoliter
type: SIO_000074
notation: pl

Unmarried
subclass of: Marital Status
notation: 46
definition: Indicates a person not currently joined in a legally binding matrimonial union.
type: QualityValue
type: Class

Analysis
definition: The value contains concentrations from the study sample
type: Class
subclass of: Analyte

Quadrapole Time-of-Flight Liquid Chromotography-Mass Spectrometry
subclass of: Liquid Chromotography-Mass Spectrometery
type: Class

millimetres of mercury
notation: mmHg
type: SIO_000074

magnetic flux density unit
type: SIO_000074
notation: MFDU

Dental Fillings
type: Class
notation: 13
subclass of: Oral Health
type: QualityValue

Fibrin present
type: Class
subclass of: SIO_001167

Monomethylarsonic Acid
type: Class
notation: Monomethylarsonic Acid
subclass of: Arsenic Species

Interleukin-23 subunit alpha
subclass of: Protein
notation: IL23
type: Class

joule
type: SIO_000074
notation: J

Private Insurance or Self Pay
notation: 51
type: QualityValue
type: Class
subclass of: Insurance

Aligent 8800 Triple Quadrupole ICP-MS
subclass of: Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
was approved by: PER-Jim-McCusker
type: Class

Winter
notation: 210
type: Class
subclass of: Season
type: QualityValue

N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine
notation: HPMMA
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class

Lymphocyte
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
subclass of: Leukocyte
type: Class

count per nanomolar
type: SIO_000074
notation: 1/nM

Car Count
editorial note: Again, this isn't related to physical properties of housing. This is more closely related to Socioeconomic Status. Consider moving it.
subclass of: Housing Characteristic
subclass of: SIO_000794
type: QuantityVariable
type: Class
definition: Total Number of Cars in the Home

Perfluorohexane-1-sulphonic acid
notation: PFHxS
type: Class
subclass of: PFC

milligram per liter
type: SIO_000074
notation: mg/L

Annual Mean Concentration
type: QualityVariable
subclass of: Mean Concentration
type: Class

2-Methylhippuric acid (ng/mL)
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: VOC2MH

Hemolyzed (covers all three levels), lipemic, and icteric
type: Class
subclass of: SIO_001167

N-Ace-S- (3, 4-Dihidxybutl)-L-Cys(ng/mL)
notation: VOCDHB
editorial note: To Do: align with CHEBI.
subclass of: Volatile Organic Compound
type: Class

Anemia
type: QualityValue
subclass of: Phenotype
notation: 128
type: Class
definition: A reduction in erythrocytes volume or hemoglobin concentration.

mono-methyl phthalate
subclass of: Phthalate
notation: mMP
type: Class

Dimethylarsinic Acid
type: Class
notation: Dimethylarsinic Acid
subclass of: Arsenic Species

Analysis Mode
type: QualityVariable
subclass of: SampleIndicator
definition: Analysis Mode
type: Class

centimeter
notation: cm
type: SIO_000074

megakaryocyte-erythroid progenitor cell

micrograms per deciliter
notation: µg/dl
type: SIO_000074

2, 3, 5, 6-Tetrachlorophenol
definition: PHYSICAL DESCRIPTION: Leaflets (from ligroin) or light beige powder. (NTP, 1992)
subclass of: Environmental Phenol
notation: TeCP2356
type: Class

Interleukin-27 subunit alpha
type: Class
notation: IL27
subclass of: Protein

Canned Food Consumption Frequency
type: Class
definition: Frequency of Canned Food Consumption.
was approved by: PER-Jeanette-Stingone
editorial note: Also want to list this under Environmental Exposures (b/c canned food has chemicals in the lining so sometimes it is used as a proxy)
type: QuantityVariable
subclass of: Diet Quantity

count per nanomolar second
notation: 1/nMs
type: SIO_000074

cubic centimeter
notation: cm3
type: SIO_000074

Drug History
notation: 14
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
type: Class

Small Molecule
type: Class
subclass of: Biomolecule
definition: A small molecule is a low molecular weight (< 900 daltons) organic compound that may help regulate a biological process, with a size on the order of 1 nm. Most drugs are small molecules.

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
notation: PHEN2_PHEN3
subclass of: Environmental Phenol
type: Class

N-ac-S-(2-carbmo-2-hydxel)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCGAM
editorial note: To Do: align with CHEBI.

white blood cell count
subclass of: SIO_000794
type: Class

Nucleic Acid Sequencing
subclass of: SIO_001007
type: Class

all-cis-docosa-4, 7, 10, 13, 16, 19-hexaenoic acid
definition: A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.
type: Class
notation: C226N3
subclass of: Fatty Acid

Sickle Cell Anemia
definition: A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
subclass of: Health Outcome
notation: 122
subclass of: SIO_010299
type: QualityValue
type: Class

Kaufman ABC Sequence Subscale
subclass of: Neurocognitive Assessment
definition: Subscale of Kaufman ABC designed to measure the ability to solve problems by remembering and using an ordered series of images or ideas
type: Class

count unit
notation: count
type: SIO_000074

Waist
subclass of: SIO_010046
type: Class
definition: The waist is the part of the abdomen between the rib cage and hips. On people with slim bodies, the waist is the narrowest part of the torso.

1-hydroxyphenanthrene
subclass of: PAH
type: Class
notation: PHEN1

Developmental Disorder of Mental Health
type: Class
subclass of: Disease

3,5,6-trichloropyridine-2-one
subclass of: Metabolite
definition: A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.
type: Class

dimethyldithiophosphate
notation: DMDP
editorial note: To Do: align with CHEBI.
subclass of: Alkyl Phosphate Pesticide Metabolite
type: Class

Budesonide/formoterol (Symbicort)
subclass of: Asthma Controller Medication
type: Class

Enzyme Immunoassay
subclass of: Immunoassay
type: Class

Perfluroundecanoic acid
notation: PFUNDA
type: Class
subclass of: PFC

Perfluorobutanesulfonic acid
subclass of: PFC
type: Class
notation: PFBS

3-phenoxybenzoic acid
definition: A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.
type: Class
subclass of: Metabolite

N-Acetyl-S-(n-propyl)-L-cysteine
subclass of: Volatile Organic Compound
notation: BPMA
type: Class
editorial note: To Do: align with CHEBI.

PCB52
subclass of: Polychlorobiphenyl
notation: PCB52
type: Class

Perfluorohexanoic acid
notation: PFHxA
type: Class
subclass of: PFC

gigabasepair
notation: Gb
type: SIO_000074

microgram per liter
notation: µg/L
type: SIO_000074

Obvious coarse debris
subclass of: SIO_001167
type: Class

electronvolt
notation: eV
type: SIO_000074

Polygamous
type: QualityValue
notation: 45
type: Class
subclass of: Marital Status
definition: A type of living arrangement or mating system in which at least one member of a relationship has more than one mate.

Bodily Fluid
subclass of: Biospecimen
definition: Liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not.
type: Class

First or Second Trimester
definition: The time period from pregnancy week 1 through 28 and includes conception.
subclass of: Restriction
  all values from: Class
    intersection of: Conceiving
  on property: inRelationTo
subclass of: SIO_000417
subclass of: From Conception
type: Class

Tellurium
notation: Te
definition: Tellurium. An element that is a member of the chalcogen family. TELLURIUM has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.
type: Class
subclass of: Metal

newton
notation: Ntn
type: SIO_000074

1-hydroxybenzo[c]-phenanthrene
subclass of: PAH
type: Class
notation: BCP1

Occupation
definition: An individual attribute that is the usual or principal work or business of an individual.
subclass of: Socioeconomic Status
subclass of: SIO_000016
type: Class
subclass of: Demographic
was approved by: PER-Jeanette-Stingone
type: QualityVariable

Cognitive Entity
type: Class
subclass of: Neurocognitive Assessment

Child
subclass of: Restriction
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Parent
    intersection of: SIO_000485
  on property: inRelationTo
was approved by: PER-Jeanette-Stingone
definition: A relationship with a parent (such as sons and daughters of any age).
subclass of: Descendant
type: Class

N-Acetyl-S- (2-carboxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
notation: CEMA

Common Era
type: Class
subclass of: Relative Time
definition: Common era time measurements are referenced against (in relation to) the beginning of the common era, 1 CE (or 1 AD).
equivalent class: Restriction
  has value: First Year of the Common Era
  on property: inRelationTo

Some Postgraduate
type: QualityValue
subclass of: Restriction
  some values from: NCIT C92860
  on property: SIO_000230
definition: Has begun postgraduate (masters, doctorate, etcl) and may or may not have matriculated with a graduate degree.
notation: 187
subclass of: Higher Education
type: Class

parts per quadrillion
notation: ppq
type: SIO_000074

millimole
notation: mmol
type: SIO_000074

Slightly hemolyzed
type: Class
subclass of: SIO_001167

Beryllium
type: Class
definition: Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.
notation: Be
subclass of: Metal

Colorimetric Assay
subclass of: SIO_001007
type: Class

Selenium
definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
type: Class
notation: Se
subclass of: Metal

oleic acid
subclass of: Fatty Acid
notation: C181N9
type: Class
definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.

Roentgen equivalent man
type: SIO_000074
notation: rem

Chloroform
definition: CHLOROFORM is a commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.
notation: CFRM
subclass of: Volatile Organic Compound
type: Class

Oily Fish
type: Class
subclass of: FOODON_03411222
definition: Oily fish are fish that contain at least 2% fat by weight. (Oily Fish. (n.d.) Segen's Medical Dictionary. (2011))

3-Hydroxypropyl-1-methyl mercapturic acid + 3-Hydroxypropyl-2-methyl mercapturic acid + 3-Hydroxypropyl-3-methyl mercapturic acid
notation: HMPMA

Feces
subclass of: Biospecimen
definition: Portion of semisolid bodily waste discharged through the anus[MW, modified] [database_cross_reference: http://en.wikipedia.org/wiki/Feces][database_cross_reference: http://www.merriam-webster.com/dictionary/feces]
type: Class

gestational diabetes
notation: 179
type: QualityValue
subclass of: DOID 9351
type: Class

kilobasepair
notation: kbp
type: SIO_000074

No Sickle Cell Anemia
type: QualityValue
subclass of: Health Outcome
notation: 138
type: Class

Daughter
subclass of: Child
subclass of: Restriction
  all values from: Restriction
    on property: hasAttribute
    some values from: SIO_010052
  on property: isRoleOf
type: Class
definition: The female offspring in relation to her parents.

Bedroom Count
type: Class
definition: Total Number of Bedrooms in the Home
subclass of: Room Count
type: QuantityVariable
was approved by: PER-Jeanette-Stingone

linoleic acid
definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
type: Class
subclass of: Fatty Acid
notation: C182N6

Apartment
type: Class
type: QualityValue
subclass of: NCIT C86029
notation: 196

MicroPEM
subclass of: Exposure Monitoring Instrument
definition: The MicroPEM device monitors individual exposures to very fine airborne particles—or particulate matter—at two sizes. PM10 has a diameter of less than 10 micrometers (PM10), which is approximately 1/30th the size of a human hair, and PM2.5, which at diameters of less than 2.5 micrometers, is even smaller.
was approved by: PER-Jim-McCusker
type: Class

Coma
subclass of: Phenotype
definition: Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli.
type: Class
type: QualityValue
notation: 124

neural cell
type: Class
subclass of: Cell

kilovolt-hour
notation: kVh
type: SIO_000074

pixels per millimeter
notation: p/mm
type: SIO_000074

Room
subclass of: Human Dwelling
type: Class
notation: 249
type: QualityValue

mono-n-butylphthalate (BzBP, DnBP)
subclass of: Phthalate
type: Class
notation: MnBP

Indoor Air
type: QualityVariable
type: Class
subclass of: ENVO_00002005
subclass of: Restriction
  on property: SIO_000128
  some values from: ExO_0000019

SpectraMax Plus 384 Microplate Reader
was approved by: PER-Jim-McCusker
definition: Get absorbance measurements from 190 to 1000 nm quickly for samples in test tubes, cuvettes, and 96- or 384-well microplates. The SpectraMax® Plus 384 Microplate Reader gives you walk-up convenience for both standard spectrophotometer and microplate reader applications on the same instrument. Monochromator wavelength selection saves you the time and trouble of ever having to change out filters. Typical applications for this powerful reader include DNA and RNA quantification, enzyme kinetic assays, and ELISA based assays. When your project is ready for high throughput, take advantage of StakMax® automated microplate handling compatibility for full robotic integration.
type: Class
subclass of: Microplate Reader

N-Acetyl-S-(2-Carbxyethyl)-L-Cys(ng/mL)
editorial note: To Do: align with CHEBI.
subclass of: Volatile Organic Compound
type: Class
notation: VOCCEM

kilogram per square meter
type: SIO_000074
notation: kg/m2

Thallium
notation: Tl
subclass of: Metal
definition: THALLIUM is a heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.
type: Class

experimentally modified cell in vitro
type: Class
subclass of: Cell

Atomic Fluorescence Spectroscopy Instrument
subclass of: PhysicalInstrument
definition: a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light.
type: Class
was approved by: PER-Jim-McCusker

Environmental Material
subclass of: SIO_010412
type: Class

liter per kilogram
notation: l/kg
type: SIO_000074

Immunoturbidimetry
type: Class
subclass of: SIO_001007
definition: An analytical technique that uses light scattering, a physical phenomenon resulting from the interaction of light with particles in solution, to measure the concentration of particles. The photometric signal is generated by a decrease in light intensity as a direct consequence of increasing turbidity in the reaction well. Immunoturbidimetry uses the classical antigen-antibody reaction. The antigen-antibody complexes are particles which can be optically detected by an photometer.
was approved by: PER-Jim-McCusker

Delivery Characteristics
type: Class
subclass of: StudyIndicator
definition: Attributes related to the delivery of a child.

Pregnancy Sample
type: Class
subclass of: Biospecimen
definition: A sample that is taken at or near pregnancy or birth.

Mercury Species
subclass of: Targeted Analyte
type: Class

millimolal
notation: mmol/kg
type: SIO_000074

diethylphosphate
subclass of: Alkyl Phosphate Pesticide Metabolite
type: Class
editorial note: To Do: align with CHEBI.
notation: DEP

2, 2', 4, 4', 6-Pentabromodiphenyl ether
notation: BDE100
editorial note: To Do: align with CHEBI.
subclass of: Polybrominated Diphenyl Ether
type: Class

Hispanic or Latino Ethnicity
type: Class
subclass of: Ethnicity
type: QualityValue
notation: 47
was approved by: PER-Jeanette-Stingone
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term “Spanish origin” can also be used in addition to “Hispanic or Latino.”

Income 30000 to 49999
type: Class
subclass of: Household Income
type: QualityValue
notation: 221

microvolt
type: SIO_000074
notation: µV

High School or Less
subclass of: Education
was approved by: PER-Jeanette-Stingone
type: Class
definition: Education Level of High School or Less
type: QualityValue
notation: 33

Ethyl mercury (C2H5Hg+)
subclass of: Mercury Species
type: Class
notation: C2H5Hg

Step
type: Class
subclass of: Non-Biological Relative
definition: A stepfamily is a family where at least one parent has children that are not genetically related to the other spouse or partner. Either one parent may have children from a previous relationship. Children in a stepfamily may live with one biological parent, or they may live with each biological parent for a period of time. In addition, visitation rights mean that children in stepfamilies often have contact with both biological parents, even if they permanently live with only one. A child is referred to as the stepchild, stepdaughter or stepson of their biological parent's new spouse, and that person as the stepparent, stepfather or stepmother of the child. A stepfather is the husband of one's mother, and not one's biological father. A stepmother is the wife of one's father, and not one's biological mother. A step-grandmother is the wife of one's grandfather, and not one's biological grandmother. A step-grandfather is the husband of one's grandmother, and not one's biological grandfather. Similarly, a stepbrother is the son of a stepparent who one is not biologically related to. A stepsister is the daughter of a stepparent to whom one is not biologically related. A step-grandson is the son of a stepson or stepdaughter who one is not biologically related to. A step-granddaughter is the daughter of a stepson or stepdaughter who one is not biologically related. A parent's spouse of the same sex may also count as a stepparent.

1-hydroxypyrene
type: Class
notation: PYR1
subclass of: PAH

nanogray
type: SIO_000074
notation: nGy

cubic meter per mole
type: SIO_000074
notation: m3/mol

N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine
subclass of: Volatile Organic Compound
notation: MHBMA2
editorial note: To Do: align with CHEBI.
type: Class

Detectable
subclass of: SIO_001167
type: Class

Mexico
notation: 183
type: QualityValue

Surface-Induced Dissociation (SID)
type: Class
subclass of: TandemMassSpectrometry

milligram per gram
type: SIO_000074
notation: mg/g

Cyclomicrons present
subclass of: SIO_001167
type: Class

milligram per milliliter
notation: mg/ml
type: SIO_000074

microcurie per milliliter
type: SIO_000074
notation: µcurie/ml

Socioeconomic Status
definition: Socioeconomic Status Indicator Class
type: Class
subclass of: StudyIndicator
was approved by: PER-Jeanette-Stingone

Limit of Detection
type: Class
subclass of: Concentration
definition: The lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.

Red blood cells present
type: Class
subclass of: SIO_001167

Cromolyn
subclass of: Asthma Controller Medication
type: Class

Intelligence Quotient
type: QuantityVariable
was approved by: PER-Jeanette-Stingone
type: Class
subclass of: SIO_000052
definition: A measure of intelligence
subclass of: Physical And Mental Assessment

SIO_000751
notation: 133
type: QualityValue

PCB153
type: Class
subclass of: Polychlorobiphenyl
notation: PCB153

Bisphenol A
subclass of: Environmental Phenol
notation: BPA
definition: 4, 4'-isopropylidenediphenol is a white to light brown flakes or powder. Has a weak medicine odor. Sinks in water. (USCG, 1999)
type: Class

4-nitrophenol
notation: PNP

thousand parts per microgram
notation: x103 µL
type: SIO_000074

N-methyl Perfluorooctane sulfonamido acetic acid
type: Class
subclass of: PFC
notation: NMFOSAA

Conceiving
subclass of: SIO_000587
comment: to become pregnant with a child.
type: Class

dalton
type: SIO_000074
notation: Da

Student
subclass of: Occupation
notation: 66
type: Class
type: QualityValue

Montelukast (Singulair)
subclass of: Asthma Controller Medication
type: Class

Airborne Particulate Matter
type: QualityVariable
subclass of: Air Pollutant
type: Class

Used Only Anti Malarials or No Medications
type: Class
type: QualityValue
subclass of: Prescription Medication and Dietary Supplements
notation: 139

Grandmother
definition: The mother of your father or mother.
type: QualityValue
subclass of: Ancestor
notation: 190
type: Class

Macromolecule
definition: A very large molecule, such as protein, commonly created by polymerization of smaller subunits (monomers). They are typically composed of thousands of atoms or more. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, carbohydrates and polyphenols) and large non-polymeric molecules (such as lipids and macrocycles).
subclass of: Biomolecule
type: Class

Takes every day
type: Class
subclass of: SIO_001292

1-hydroxynaphthalene
notation: NAP1
type: Class
subclass of: PAH

Electrospray Ionization Mass Spectrometry
subclass of: MassSpectrometry
definition: Mass spectrometry using ESI is called electrospray ionization mass spectrometry (ESI-MS) or, less commonly, electrospray mass spectrometry (ES-MS). ESI is a so-called 'soft ionization' technique, since there is very little fragmentation. This can be advantageous in the sense that the molecular ion (or more accurately a pseudo molecular ion) is always observed, however very little structural information can be gained from the simple mass spectrum obtained. This disadvantage can be overcome by coupling ESI with tandem mass spectrometry (ESI-MS/MS). Another important advantage of ESI is that solution-phase information can be retained into the gas-phase.
was approved by: PER-Jim-McCusker
type: Class

Interleukin-13
type: Class
notation: IL13
subclass of: Protein

Tri-Cell DMA-80 Direct Mercury Analyzer
was approved by: PER-Jim-McCusker
subclass of: Direct Mercury Analyzer
definition: The DMA-80 is based on the principles of sample thermal decomposition, mercury amalgamation and atomic absorption detection. The DMA-80 has been used to develop the US EPA method 7473 (Mercury in solids and solutions by thermal decomposition, amalgamation, and atomic absorption spectrophotometry). It is furthermore compliant with ASTM method D-6722-01 (Total mercury in coal and coal combustion residues) and ASTM method D-7623-10 (Total mercury in crude oil).
type: Class

Cousin
type: Class
definition: A person belonging to the same extended family.
subclass of: Relative

picosecond
notation: ps
type: SIO_000074

micromolar
type: SIO_000074
notation: µM

Reichert AR200 Handheld Digital Refractometer
was approved by: PER-Jim-McCusker
type: Class
subclass of: Refractometer
definition: Lightweight digital refractometer designed for the food, beverage, agricultural, industrial-fluid, chemical, petrochemical, pharmaceutical, medical, and plastic industries.

Air Pollutant
type: Class
type: QualityVariable
subclass of: Environmental Exposure

N-Acetyl-S-(phenyl)-L-cysteine(ng/mL)
subclass of: Volatile Organic Compound
editorial note: To Do: align with CHEBI.
type: Class
notation: VOCPMA

Household
subclass of: SIO_001064
definition: A household consists of one or more people who live in the same dwelling and also share meals or living accommodation, and may consist of a single family or some other grouping of people. A single dwelling will be considered to contain multiple households if either meals or living space are not shared. The household is the basic unit of analysis in many social, microeconomic and government models, and is important to the fields of economics and inheritance.
subclass of: Housing Characteristic
type: Class

Buccal Cell
subclass of: Cell
type: Class
definition: Cells collected from the inner epithelium of the cheek

Triclosan
subclass of: Environmental Phenol
type: Class
definition: Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
notation: TCS

Reverse-Phase Mass Spectrometry Profiling
subclass of: MassSpectrometry
type: Class

Room Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable
subclass of: SIO_000794
definition: Total Number of Rooms in the Home
type: Class
subclass of: Housing Characteristic

Arsenic Species
subclass of: Targeted Analyte
definition: A molecular entity with arsenic components.
type: Class

Bisulfite Pyrosequencing
subclass of: Nucleic Acid Sequencing
type: Class

Known Food Allergies
subclass of: Health Outcome
type: Class
type: QualityVariable

nanometer
type: SIO_000074
notation: nm

E-Cigarette Use
type: Class
type: QualityVariable
subclass of: Active Smoker

Unusual color
type: Class
subclass of: SIO_001167

count per molar second
type: SIO_000074
notation: 1/Ms

Neptunium
notation: Np
subclass of: Metal
type: Class
definition: Neptunium. A radioactive element of the actinide metals family. NEPTUNIUM has the atomic symbol Np, atomic number 93, and atomic weight 237.

4-hydroxyphenanthrene
subclass of: PAH
notation: PHEN4
type: Class

N-Ac-S-(2-Hydrxy-3-butnyl)-L-Cys(ng/mL)
subclass of: Volatile Organic Compound
notation: VOCMB2
editorial note: To Do: align with CHEBI.
type: Class

American Indian Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: American Indian Or Alaskan Native
notation: 218

Severe Malarial Anemia
notation: 127
definition: In holoendemic transmission areas, Severe Malarial Anemia (SMA) is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases. Mortality rates from SMA can exceed 30% in pediatric populations residing in holoendemic transmission areas. The pathophysiological processes that contribute to SMA involve direct and indirect destruction of parasitized and non-parasitized red blood cells (RBCs), inefficient and/or suppression of erythropoiesis, and dyserythropoiesis.
subclass of: Anemia
type: QualityValue
type: Class

Atomic Spectroscopy
subclass of: Spectroscopy
type: Class

times per two weeks
type: SIO_000074
notation: times / two weeks
type: SIO_000794

Interleukin-31
subclass of: Protein
notation: IL31
type: Class

9-hydroxyfluorene
notation: FLUO9
type: Class
subclass of: PAH

milligram
type: SIO_000074
notation: mg

Lipemic
type: Class
subclass of: SIO_001167

poise
type: SIO_000074
notation: Poise

Chief Complaint
type: Class
subclass of: Health Outcome
type: QualityVariable

No Insurance / Self-funded
notation: 89
type: Class
subclass of: Private Insurance or Self Pay
type: QualityValue

microgram
type: SIO_000074
notation: µg

microeinstein per square meter per second
notation: µeinstein/sm2
type: SIO_000074

kibibyte
type: SIO_000074
notation: KiB

Interleukin-12 subunit alpha
type: Class
notation: IL12P70
subclass of: Protein

m-Xylene*
definition: M-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)
notation: MXY
subclass of: Volatile Organic Compound
type: Class

compound eye retinal cell
type: Class
subclass of: Cell

Broken Mitest
subclass of: SIO_001167
type: Class

SIO_010048
notation: 111
type: QualityValue

Eats Oily Fish
subclass of: Dietary Intake
subclass of: Restriction
  on property: SIO SIO 000369
  some values from: Oily Fish
type: QualityValue
type: Class
notation: 226
definition: The attribute of eating oily fish.

picometer
notation: pm
type: SIO_000074

HPLC with Fluorescence Level Detector
definition: HPLC paired with a Fluorescence Level Detector. Fluorescence spectroscopy (also known as fluorometry or spectrofluorometry) is a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light. A complementary technique is absorption spectroscopy. In the special case of single molecule fluorescence spectroscopy, intensity fluctuations from the emitted light are measured from either single fluorophores, or pairs of fluorophores.
subclass of: High-Performance Liquid Chromatography
type: Class

Hydrogen–Deuterium Exchange Mass Spectrometer
subclass of: Mass Spectrometer
type: Class
definition: Hydrogen–deuterium exchange mass spectrometry can determine the overall deuterium content of molecules which have undergone H/D exchange. Because of the sample preparation required, it is typically considered to provide an accurate measurement of non-exchangeable hydrogen atoms only.
was approved by: PER-Jim-McCusker

3-Methylhippuric acid + 4-Methylhippuric acid
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound
notation: MHA34

Fluticasone propionate HFA (Flovent HFA)
type: Class
subclass of: Asthma Controller Medication

Benzene
subclass of: Volatile Organic Compound
type: Class
notation: BZ
definition: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

Aluminum
subclass of: Metal
type: Class
notation: Al
definition: ALUMINUM is a metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

Patella
subclass of: SIO_010046
definition: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella.
type: Class

kelvin
type: SIO_000074
notation: K

Perfluoroheptanoic acid
subclass of: PFC
type: Class
notation: PFHPA

microgram per gram
type: SIO_000074
notation: ug/g

Neighborhood Characteristic
subclass of: StudyIndicator
definition: Neighborhood Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone
type: Class

all-cis-5, 8, 11, 14, 17-icosapentaenoic acid
type: Class
definition: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.
notation: C205N3
subclass of: Fatty Acid

mass density unit
type: SIO_000074
notation: mdu

Cognitive Task
type: Class
subclass of: Neurocognitive Assessment

RNA
subclass of: Macromolecule
type: Class

PFC
type: Class
subclass of: Targeted Analyte

Mean Body Weight
type: Class
subclass of: Body Weight Quality
type: QuantityVariable
subclass of: SIO_001109

micromole
type: SIO_000074
notation: µmol

From Conception
type: Class
subclass of: Relative Time
definition: A time in relation to a conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving

thawed, hemolyzed (covers all three levels) and exposed to light
type: Class
subclass of: SIO_001167

parts per thousand
notation: ppth
type: SIO_000074

Inductively Coupled Plasma Mass Spectrometry
subclass of: MassSpectrometry
type: Class

Destination
definition: A place to which one is traveling or to which something is sent.
subclass of: Healthcare Access
type: QualityVariable
type: Class
notation: Dest

California
notation: 185
type: QualityValue

SIO_001068
notation: 135
type: QualityValue

Protein
subclass of: Biological Response
type: Class

thawed and clotted
type: Class
subclass of: SIO_001167

Interleukin-5
notation: IL5
type: Class
subclass of: Protein

No Formal Education
subclass of: Education
was approved by: PER-Jeanette-Stingone
definition: Has not been educated in a formal setting.
type: QualityValue
type: Class
notation: 57

Only takes with symptoms
subclass of: SIO_001290
type: Class

Ethyl paraben
definition: Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of ethylparaben is Allergens.
type: Class
notation: EtPB
subclass of: Paraben

4-Chlorophenol
type: Class
subclass of: Environmental Phenol
definition: P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.
notation: MCP4

Moderately hemolyzed
subclass of: SIO_001167
type: Class

megabyte
notation: MB
type: SIO_000074

unit per milliliter
type: SIO_000074
notation: U/ml

USC Obstetrics-Gynecology
notation: 271
type: Class
type: QualityValue
subclass of: Population Group

Small clot present
type: Class
subclass of: SIO_001167

Lithium
subclass of: Metal
notation: Li
definition: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
type: Class

Biospecimen
type: Class
subclass of: SIO_010412
definition: A biological laboratory specimen held by a biorepository for research. Such a specimen would be taken by sampling so as to be representative of any other specimen taken from the source of the specimen. When biological specimens are stored, ideally they remain equivalent to freshly-collected specimens for the purposes of research.

Perfluorooctanoic acid
subclass of: PFC
type: Class
notation: PFOA

Zinc
subclass of: Metal
notation: Zn
type: Class
definition: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Nail
type: Class
definition: A nail that is part of a manual digit. [database_cross_reference: OBOL:automatic]
subclass of: Tissue

Competitive-inhibition enzyme-linked immunosorbent assay
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)

Home
notation: 167
subclass of: Destination
type: Class
definition: A person's place of residence.
type: QualityValue

3-hydroxychrysene
type: Class
notation: CHRY3
subclass of: PAH

Protocatechuic acid ethyl ester
notation: OHEtP
subclass of: Environmental Phenol
type: Class

Phenanthrene tetrol
notation: PHET

square meter
type: SIO_000074
notation: m2

mono-isononyl phthalate
type: Class
subclass of: Phthalate
notation: mINP

Entity
subclass of: ScienceIndicator
type: Class

square centimeter
notation: cm2
type: SIO_000074

Sample older than 2 weeks
type: Class
subclass of: SIO_001167

Metabolite
definition: A substance formed in or necessary for metabolism
type: Class
subclass of: Analyte

Nitrogen Oxides
label: Nitrogen Oxide
type: QualityVariable
subclass of: Metabolite
subclass of: Air Pollutant
type: Class

Run out-of-contol; insufficient sample for repeat analysis
type: Class
subclass of: SIO_001167

Cord Blood
subclass of: Whole Blood
subclass of: Pregnancy Sample
definition: Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Cord_blood]
type: Class

Infrared Multiphoton Dissociation (IRMPD)
type: Class
subclass of: TandemMassSpectrometry

Whole Blood
definition: A fluid that is composed of blood plasma and erythrocytes. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Blood][database_cross_reference: https://github.com/obophenotype/uberon/issues/9][database_cross_reference: FMA:9670]
type: Class
subclass of: Bodily Fluid

picomoles per milliliter
type: SIO_000074
notation: pmol/ml

SO_0000000
deprecated: true

meter
type: SIO_000074
notation: m

microsecond
notation: µs
type: SIO_000074

gram per deciliter
notation: g/dl
type: SIO_000074

Exposure Monitoring Instrument
definition: A physical instrument that monitors the environment for chemical exposures.
type: Class
was approved by: PER-Jim-McCusker
subclass of: PhysicalInstrument

Ciclesonide HFA (Alvesco)
type: Class
subclass of: Asthma Controller Medication

Pathogen Transmission
subclass of: Process

Failed positive control
type: Class
subclass of: SIO_001167

Sleep Characterisitic
definition: Sleep Characterisitics Indicator Class
subclass of: StudyIndicator
type: Class
was approved by: PER-Jeanette-Stingone

second
notation: s
type: SIO_000074

kilogram
type: SIO_000074
notation: kg

Takes some days but not others
type: Class
subclass of: SIO_001290

pre-eclampsia
type: Class
type: QualityValue
subclass of: DOID_0050828
notation: 177

Daily E-Cigarette Use
type: QualityValue
subclass of: E-Cigarette Use
notation: 156
type: Class

Alkyl Phosphate Pesticide Metabolite
type: Class
subclass of: Targeted Analyte

volt
type: SIO_000074
notation: Volt

Income 5001 to 15000
definition: Personal or family annual income bwtween $5,001 and $15,000
notation: 160
subclass of: Household Income
type: Class
type: QualityValue

Earth
type: QualityValue
notation: 182

gram per mole
type: SIO_000074
notation: g/mol

esophageal disease
subclass of: SIO_010299
type: Class

cubic decimeter
notation: dm3
type: SIO_000074

Income 20001 to 40000
type: QualityValue
type: Class
subclass of: Household Income
notation: 206

microunits per milliliter
notation: µU/mL
type: SIO_000074

Cyclohexane-1, 2-dicarboxylic acid mono hydroxyisononyl ester (DINCH)
notation: MHNCH

katal
type: SIO_000074
notation: kat

milliliter per liter
notation: ml/l
type: SIO_000074

Domestic Partnership
type: QualityValue
notation: 42
type: Class
definition: Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered.
subclass of: Unmarried

Parous
notation: 73
type: Class
subclass of: Parity
type: QualityValue

native cell
type: Class
subclass of: Cell

4-(methlynitrosamino)-1-(3-pyridyl)-1-butanol
editorial note: To Do: align with CHEBI.
subclass of: Tobacco Metabolite
notation: NNAL
type: Class

Clinical Measurement
type: Class
definition: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.
subclass of: Physical And Mental Assessment

Adopted
type: Class
definition: Adoption is a process whereby a person assumes the parenting of another, usually a child, from that person's biological or legal parent or parents, and, in so doing, permanently transfers all rights and responsibilities, along with filiation, from the biological parent or parents.
subclass of: Non-Biological Relative

N-acel-S-(1, 2-dichlorovinl)-L-cys(ng/mL)
notation: VOC1DC
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound

nanogram per gram
type: SIO_000074
notation: ng/g

Zileuton (Zyflo)
subclass of: Asthma Controller Medication
type: Class

SIO_000980
notation: 107
type: QualityValue

Employment
notation: 245
type: QualityValue
subclass of: Occupation
type: Class

UBERON_0036255
deprecated: true

Budesonide nebulized (Pulmicort)
subclass of: Asthma Controller Medication
type: Class

Arsenous ( III) Acid
type: Class
notation: Arsenous (III) Acid
subclass of: Arsenic Species

kilogram per liter
notation: kg/L
type: SIO_000074

Disease
subclass of: SIO_010299
type: Class
subclass of: Health Outcome

Income more than 70001
notation: 208
type: Class
type: QualityValue
subclass of: Household Income

Interleukin-17A
notation: IL17A
type: Class
subclass of: Protein

Mean Height
type: Class
subclass of: Height
type: QuantityVariable
subclass of: SIO_001109

parasites per microgram
type: SIO_000074
notation: parasites/µL

watt per square meter
notation: W/m2
type: SIO_000074

(9Z)-hexadecenoic acid
definition: A hexadecenoic acid with a cis-double bond at position C-9.
subclass of: Fatty Acid
notation: C161N7
type: Class

Tobacco Metabolite
subclass of: Targeted Analyte
type: Class

kilovolt
notation: kV
type: SIO_000074

4, 4'-(hexafluoroisopropylidene)-dephenol
notation: BPAF

PCB138
notation: PCB138
subclass of: Polychlorobiphenyl
type: Class

N-Acetyl-S- (2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HEMA2

centiRay
notation: cR
type: SIO_000074

Cis-Chlordane
type: Class
subclass of: Organochlorine Compound
notation: CCHL

hemoglobin measurement
type: Class
subclass of: Concentration

N-Ethyl Perfluorooctane sulfonamido acetic acid
notation: NETFOSAA

microliters per minute
notation: µL/min
type: SIO_000074

Initial concentration higher than the highest standard, insufficient volume for repeat analysis (93, 18)
type: Class
subclass of: SIO_001167

Computer
type: Class
definition: A machine used for computation and much more.
subclass of: Household Appliance Count
was approved by: PER-Jeanette-Stingone
type: QuantityVariable

plaque forming unit per milliliter
type: SIO_000074
notation: pfu/ml

4, 4'-cyclo-hexylidenebisphenol
notation: BPZ

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine
notation: MHBMA3
editorial note: To Do: align with CHEBI.
type: Class
subclass of: Volatile Organic Compound

1-hydroxybenz[a]anthacene
notation: BAA1
subclass of: PAH
editorial note: Only found in one journal article, no where else. Maybe mis-spelled?
type: Class

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
notation: PHEN2PHEN3

nanoliter
type: SIO_000074
notation: nl

2, 2'-bis(4-hydroxyphenyl)butane
notation: BPB

Fluticasone propionate DPI (Flovent Diskus)
subclass of: Asthma Controller Medication
type: Class

Methyl mercury (CH3Hg+)
notation: CH3Hg
type: Class
subclass of: Mercury Species

4, 4′-(1, 4-Phenylenediisopropylidene)bisphenol
notation: BPP

HUC sample having discrepancy between fluorometer results and semi quantative Albustix test results
type: Class
subclass of: SIO_001167

millisievert
type: SIO_000074
notation: mSv

kilogram per cubic meter
type: SIO_000074
notation: kg/m3

3-methipurc acd, 4-methipurc acd(ng/mL)
notation: VOC34M
subclass of: Volatile Organic Compound
type: Class
editorial note: To Do: align with CHEBI.

hematocrit
subclass of: SIO_001018
type: Class

Stromelysin-2
subclass of: Protein
type: Class
notation: MMP10

Trans-Chlordane
notation: TCHL
subclass of: Organochlorine Compound
type: Class

Liquid Chromotography -tandem mass spectrometry
subclass of: MassSpectrometry
type: Class

mole fraction
notation: chi
type: SIO_000074

watt per steradian per square meter
type: SIO_000074
notation: W/sr/m2

Birthplace
type: QualityVariable
definition: The place where a person was born.
subclass of: Demographic
subclass of: Location
type: Class

Blackbody Infrared Radiative Dissociation (BIRD)
type: Class
subclass of: TandemMassSpectrometry

Paraben
type: Class
subclass of: Targeted Analyte

watt-hour
notation: Wh
type: SIO_000074

Liquid Chromotography-Mass Spectrometery
type: Class
subclass of: MassSpectrometry

First Year of the Common Era
type: NamedIndividual

Trimethylarsine oxide
type: Class
notation: Trimethylarsine oxide
subclass of: Arsenic Species

Diet and Nutrition
subclass of: StudyIndicator
type: Class
was approved by: PER-Jeanette-Stingone
definition: Diet and Nutrition Indicator

radian
notation: rad
type: SIO_000074

enzyme unit
type: SIO_000074
notation: enzyme unit

mass-to-charge ratio
notation: Th
type: SIO_000074

platelet count
type: Class
subclass of: SIO_000794

mebibyte
type: SIO_000074
notation: MiB

Asthma Controller Medication
type: Class
subclass of: SIO_010039
definition: A class of pharmeceutical drugs that are used to prevent or manage the onset of acute asthma before an attack occurs.

Cyclohexane-1, 2-dicarboxylic acid mono carboxyisooctyl ester (DINCH)
notation: MCOCH

Behavioral Experimental Paradigm
type: Class
subclass of: Neurocognitive Assessment

Cell

first:
  max exclusive: 15
rest: nil

rest: nil
first:
  max exclusive: 25

Datatype
on datatype: float
with restrictions:
  max exclusive: 25.0

Datatype
with restrictions:
  min inclusive: 15
on datatype: integer

Datatype
with restrictions:
  min exclusive: 25.0
on datatype: float

rest:
  first: Datatype
  rest: nil
first: Datatype
  on datatype: float
  with restrictions:
    min exclusive: 18.5

Restriction
on property: hasValue
all values from: Datatype
  on datatype: integer
  with restrictions:
    min exclusive: 25

Datatype
with restrictions:
  min exclusive: 25.0
on datatype: float

rest: nil
first:
  max exclusive: 29.9

Datatype
with restrictions:
  min exclusive: 29.9
on datatype: float

Datatype
on datatype: float
with restrictions:
  max exclusive: 18.5

first:
  max exclusive: 25.0
rest: nil